Cruise itinerary
16-Night Rhine Cruise from Prague
16 nights · Rhine · 13 ports of call
16-night Rhine cruise aboard Scenic Opal, departing Prague and calling at Budapest, Vienna, Dürnstein, Melk, Passau and Regensburg and 6 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Scenic Opal
- Cruise line
- Scenic
- Duration
- 16 nights
- Region
- Rhine · Europe
- Departs
- Prague
- Returns
- Amsterdam
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Scenic Opal sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Prague
The Czech capital, a near-intact medieval city on the Vltava in central Europe. Its hilltop castle, the Charles Bridge and the astronomical clock in the Old Town Square draw river travellers calling along this stretch of the continent.
- Charles Bridge
- Prague Castle
- Old Town Square
- Day2At sea
- Day3At sea
- Day4
Budapest
Hungary's grand capital, split by the Danube into hilly Buda and flat Pest. River ships moor in the centre, within reach of the neo-Gothic Parliament, the thermal baths at Széchenyi and the panoramic ramparts of Fisherman's Bastion.
- Parliament Building
- Széchenyi Baths
- Fisherman's Bastion
- Day5At sea
- Day6At sea
- Day7
Vienna
Austria's imperial capital on the Danube, long the seat of the Habsburgs. River ships call within reach of Schönbrunn Palace, the Hofburg and St. Stephen's Cathedral, in a city famed for coffee houses, classical music and grand ringstrasse architecture.
- Schönbrunn Palace
- St. Stephen's Cathedral
- Coffee houses
- Day8
Melk
A small town on the Danube at the western edge of Austria's Wachau Valley, dominated by a vast Baroque abbey on a rocky ridge. Melk Abbey's gilded library and church draw river-cruise passengers passing through the wine region.
- Melk Abbey
- Abbey library
- Wachau Valley
- Day9
Passau
A Bavarian city where the Danube, Inn and Ilz rivers meet, near the Austrian border. Long a starting point for Danube cruises, its baroque old town centres on St. Stephen's Cathedral, home to one of the largest church organs in the world.
- Three rivers
- St. Stephen's Cathedral
- Baroque old town
- Day10
Regensburg
A Bavarian city on the Danube with one of Germany's best-preserved medieval centres. River ships call within walking distance of the 12th-century Stone Bridge, the Gothic cathedral and a tangle of lanes lined with patrician towers.
- Stone Bridge
- Regensburg Cathedral
- Medieval old town
- Day11
Nuremberg
A Bavarian city on the Pegnitz with a walled medieval core and an imperial castle above it. River ships call here along the Main–Danube corridor, within reach of the old town's half-timbered houses and the famous grilled Nürnberger sausages.
- Imperial Castle
- Old town walls
- Nürnberger sausages
- Day12
Bamberg
A Bavarian town built across seven hills above the river Regnitz, its medieval and baroque core preserved as a whole. A painted town hall stands on an island mid-river, and the town is known for its smoked Rauchbier and many small breweries.
- Old Town Hall
- Bamberg Cathedral
- Smoked beer
- Day13
Würzburg
A Bavarian city on the river Main, at the start of Germany's Romantic Road. The hillside Marienberg fortress overlooks the old town and the vineyards along the river, while the baroque Residenz palace anchors the centre with its grand frescoed staircase.
- Marienberg Fortress
- Würzburg Residenz
- Old Main Bridge
- Day14At sea
- Day15
Rüdesheim am Rhein
A wine town on the Rhine in Germany's Rheingau, set among steep Riesling vineyards. Its narrow Drosselgasse lane is lined with taverns, and a cable car rises to the Niederwald monument overlooking the river gorge.
- Drosselgasse lane
- Niederwald monument
- Rheingau vineyards
- Day16
Cologne
A Rhineland city dominated by its twin-spired Gothic cathedral, the tallest in Germany when built. River cruises call beside the old town, where the cathedral, riverside promenade and 12 Romanesque churches sit within easy walking distance.
- Cologne Cathedral
- Old town
- Rhine promenade
- Day17
Amsterdam
The Dutch capital, laced with concentric canals and gabled merchant houses from its 17th-century golden age. Most river sailings depart from here, leaving time for the Rijksmuseum, the Anne Frank House or a stroll through the Jordaan before lines cast off.
- Rijksmuseum
- Anne Frank House
- Jordaan canals
Upcoming departures
- 19 Dec 2026
- 20 Mar 2027
- 3 Nov 2027
- 18 Dec 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
16-Night Rhine Cruise from Prague FAQ
Which ports does this cruise visit?
This 16-night Rhine cruise calls at Prague, Budapest, Vienna, Dürnstein, Melk, Passau, Regensburg, Nuremberg, Bamberg, Würzburg, Rüdesheim am Rhein, Cologne and Amsterdam.
How many days are spent at sea?
5 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Prague and ends in Amsterdam.
How long is this cruise?
16 nights aboard Scenic Opal.
When does this itinerary sail?
Upcoming departures include 19 Dec 2026, 20 Mar 2027, 3 Nov 2027 and 18 Dec 2027. A NestCruise advisor can confirm current availability.