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MS Santa Cruz II — 378-Night Galapagos Islands Cruise from Callao-Lima
MS Santa Cruz II

Cruise itinerary

378-Night Galapagos Islands Cruise from Callao-Lima

378 nights · Galapagos Islands · 15 ports of call

378-night Galapagos Islands cruise aboard MS Santa Cruz II, departing Callao-Lima and calling at flight, Cusco-Machu Picchu, Quito, Baltra Island, Santa Cruz Island and Isabela Island and 8 more.

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  • No booking fees
  • 10,000+ sailings
Narrow your sailing dates See the day-by-day

At a glance

Ship
MS Santa Cruz II
Cruise line
HX Expeditions
Duration
378 nights
Region
Galapagos Islands
Departs
Callao-Lima
Returns
Guayaquil

How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact MS Santa Cruz II sailing, typically within 24 hours.

Where this voyage takes you

Callao-LimaQuitoBaltra IslandSanta Cruz IslandFloreana IslandAcajutlaGuayaquil
Voyage route — calls shown in order; map is schematic.

Day-by-day itinerary

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    • Callao-Lima

      Callao-Lima

      Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.

      • Gateway to Lima
      • Miraflores
      • Historic centre
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    • Callao-Lima

      Callao-Lima

      Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.

      • Gateway to Lima
      • Miraflores
      • Historic centre
  366. Day
    366

    • Cusco-Machu Picchu

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    • Quito

      Quito

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    • Santa Cruz Island

      Santa Cruz Island

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    • Fernandina Island

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    • Santa Cruz Island

      Santa Cruz Island

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    • Floreana Island

      Floreana Island

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    • Santa Cruz Island

      Santa Cruz Island

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    • Santiago Island

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    377
    • Acajutla

      Acajutla

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    378

    • Genovesa Island

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    379
    • Guayaquil

      Guayaquil

Upcoming departures

  • 1 Aug 2026
  • 29 Aug 2026
  • 12 Sep 2026
  • 2 Jan 2027
  • 16 Jan 2027
  • 30 Jan 2027
  • 13 Feb 2027
  • 27 Feb 2027
  • 13 Mar 2027
  • 27 Mar 2027
  • 10 Apr 2027
  • 8 May 2027

Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.

378-Night Galapagos Islands Cruise from Callao-Lima FAQ

Which ports does this cruise visit?

This 378-night Galapagos Islands cruise calls at Callao-Lima, flight, Cusco-Machu Picchu, Quito, Baltra Island, Santa Cruz Island, Isabela Island, Fernandina Island, Floreana Island, Champion Island, Santiago Island, Rabida Island, Acajutla, Genovesa Island and Guayaquil.

How many days are spent at sea?

366 days are spent at sea; the rest are in port.

Where does this cruise depart from?

It departs from Callao-Lima and ends in Guayaquil.

How long is this cruise?

378 nights aboard MS Santa Cruz II.

When does this itinerary sail?

Upcoming departures include 1 Aug 2026, 29 Aug 2026, 12 Sep 2026 and 2 Jan 2027. A NestCruise advisor can confirm current availability.

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About: MS Santa Cruz II — 378-Night Galapagos Islands Cruise from Callao-Lima

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Who’s travelling
Adults
18+
2
Children
2–17 years
0
Infants
6–23 months
0
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