

Cruise itinerary
14-Night Mediterranean Cruise from Civitavecchia-Rome
14 nights · Mediterranean · 9 ports of call
14-night Mediterranean cruise aboard Queen Elizabeth, departing Civitavecchia-Rome and calling at La Spezia, Genoa, Villefranche-sur-Mer, Ajaccio, Barcelona and Messina and 2 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Queen Elizabeth
- Cruise line
- Cunard
- Duration
- 14 nights
- Region
- Mediterranean
- Departs
- Civitavecchia-Rome
- Returns
- Istanbul
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Queen Elizabeth sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1

Civitavecchia-Rome
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day2At sea
- Day3

La Spezia
A port at the head of a gulf on Italy's Ligurian coast, the gateway to the Cinque Terre and Tuscany. La Spezia is known for its naval harbour and waterfront gardens, with the five cliffside fishing villages and the marble city of Carrara nearby.
- Cinque Terre
- Portovenere
- Carrara marble
- Day4

Genoa
Italy's great maritime city, stacked up the Ligurian hills above one of the Mediterranean's busiest harbours. Its old town is a maze of tall, narrow caruggi, and it claims pesto and focaccia as local inventions; the Aquarium and Renaissance palaces of Via Garibaldi sit close to the port.
- Old-town caruggi
- Genoa Aquarium
- Via Garibaldi palaces
- Day5

Villefranche-sur-Mer
A deep-water bay on the French Riviera between Nice and Monaco, framed by steep pastel hillsides. The sheltered harbour is a classic tender anchorage, with a baroque old town behind the waterfront and easy connections along the coast to Nice and Monte Carlo.
- Old town
- Riviera coast
- Nice & Monaco access
- Day6

Ajaccio
The capital of Corsica and Napoleon's birthplace, set on a sheltered gulf on the island's west coast. Ajaccio is known for its Bonaparte family house, the citadel and old town, and the rugged Sanguinaires islands off the harbour mouth.
- Maison Bonaparte
- Sanguinaires islands
- Ajaccio citadel
- Day7At sea
- Day8

Barcelona
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
- Day9At sea
- Day10

Messina
A Sicilian port on the strait that separates the island from mainland Italy, framed by the Peloritani mountains. Its harbour clock tower performs an elaborate noon display, and the town is a common gateway to Taormina and the slopes of Mount Etna.
- Etna day trips
- Taormina gateway
- Astronomical clock
- Day11At sea
- Day12

Piraeus-Athens
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day13At sea
- Day14At sea
- Day15

Istanbul
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
Upcoming departures
- 24 Sep 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
14-Night Mediterranean Cruise from Civitavecchia-Rome FAQ
Which ports does this cruise visit?
This 14-night Mediterranean cruise calls at Civitavecchia-Rome, La Spezia, Genoa, Villefranche-sur-Mer, Ajaccio, Barcelona, Messina, Piraeus-Athens and Istanbul.
How many days are spent at sea?
6 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Civitavecchia-Rome and ends in Istanbul.
How long is this cruise?
14 nights aboard Queen Elizabeth.
When does this itinerary sail?
Upcoming departures include 24 Sep 2027. A NestCruise advisor can confirm current availability.