Cruise itinerary
15-Night World Cruise Cruise from Los Angeles, California
15 nights · World Cruise · 8 ports of call
15-night World Cruise cruise aboard MSC Poesia, departing Los Angeles, California and calling at San Diego, California, Cabo San Lucas, Puntarenas, Cruising Panama Canal, Colón and Cartagena and 1 more.
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At a glance
- Ship
- MSC Poesia
- Cruise line
- MSC Cruises
- Duration
- 15 nights
- Region
- World Cruise
- Departs
- Los Angeles, California
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact MSC Poesia sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Los Angeles, California
Depart 21:00
The sprawling Pacific gateway of southern California, with most cruises sailing from the neighbouring Port of Los Angeles at San Pedro. The morning leaves time for Hollywood, the beaches at Santa Monica or the galleries downtown before departure.
- Hollywood
- Santa Monica Pier
- Getty Center
- Day2
San Diego, California
Arrive 08:00 · Depart 18:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day3At sea
- Day4At sea
- Day5
Cabo San Lucas
Arrive 07:00 · Depart 16:00
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day6At sea
- Day7At sea
- Day8At sea
- Day9
Puntarenas
Arrive 10:00 · Depart 20:00
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day10At sea
- Day11
Cruising Panama Canal
Arrive 09:00 · Depart 09:15
Cruising Panama Canal
Arrive 21:00 · Depart 21:15
- Day12
Colón
Arrive 07:00 · Depart 19:00
A Caribbean port at the Atlantic entrance to the Panama Canal, the usual landing for ships transiting or calling at the isthmus. The historic Gatún Locks and rainforest waterways lie close by, along with the duty-free trade zone and the old fortifications of Portobelo.
- Gatún Locks
- Panama Canal
- Portobelo forts
- Day13
Cartagena
Arrive 11:00 · Depart 18:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day14At sea
- Day15At sea
- Day16
Miami, Florida
Arrive 07:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 2 Oct 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
15-Night World Cruise Cruise from Los Angeles, California FAQ
Which ports does this cruise visit?
This 15-night World Cruise cruise calls at Los Angeles, California, San Diego, California, Cabo San Lucas, Puntarenas, Cruising Panama Canal, Colón, Cartagena and Miami, Florida.
How many days are spent at sea?
9 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Los Angeles, California and ends in Miami, Florida.
How long is this cruise?
15 nights aboard MSC Poesia.
When does this itinerary sail?
Upcoming departures include 2 Oct 2026. A NestCruise advisor can confirm current availability.