Cruise itinerary
4-Night World Cruise Cruise from Civitavecchia
4 nights · World Cruise · 5 ports of call
4-night World Cruise cruise aboard MSC Opera, departing Civitavecchia and calling at Genoa, Livorno, Marseille and Barcelona.
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- No booking fees
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At a glance
- Ship
- MSC Opera
- Cruise line
- MSC Cruises
- Duration
- 4 nights
- Region
- World Cruise
- Departs
- Civitavecchia
- Returns
- Barcelona
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact MSC Opera sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Civitavecchia
Depart 19:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day2
Genoa
Arrive 08:00 · Depart 18:00
Italy's great maritime city, stacked up the Ligurian hills above one of the Mediterranean's busiest harbours. Its old town is a maze of tall, narrow caruggi, and it claims pesto and focaccia as local inventions; the Aquarium and Renaissance palaces of Via Garibaldi sit close to the port.
- Old-town caruggi
- Genoa Aquarium
- Via Garibaldi palaces
- Day3
Livorno
Arrive 08:00 · Depart 18:00
A Tuscan port on the Ligurian Sea and the gateway to Florence and Pisa. Ships dock here for excursions to Renaissance galleries and the Leaning Tower, while Livorno itself is known for its canal district and a seafood stew called cacciucco.
- Gateway to Florence
- Pisa excursions
- Venezia Nuova canals
- Day4
Marseille
Arrive 09:00 · Depart 18:00
France's oldest city and biggest Mediterranean port, set around the old harbour of the Vieux-Port. The hilltop basilica of Notre-Dame de la Garde watches over the bay, with the Calanques inlets and bouillabaisse stalls a short way off.
- Vieux-Port
- Notre-Dame de la Garde
- Calanques
- Day5
Barcelona
Arrive 07:00
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
Upcoming departures
- 29 Oct 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
4-Night World Cruise Cruise from Civitavecchia FAQ
Which ports does this cruise visit?
This 4-night World Cruise cruise calls at Civitavecchia, Genoa, Livorno, Marseille and Barcelona.
How many days are spent at sea?
This is a port-intensive itinerary with no full days at sea.
Where does this cruise depart from?
It departs from Civitavecchia and ends in Barcelona.
How long is this cruise?
4 nights aboard MSC Opera.
When does this itinerary sail?
Upcoming departures include 29 Oct 2026. A NestCruise advisor can confirm current availability.