MSC Opera — 25-Night World Cruise Cruise from Civitavecchia

Cruise itinerary

25-Night World Cruise Cruise from Civitavecchia

25 nights · World Cruise · 15 ports of call

25-night World Cruise cruise aboard MSC Opera, departing Civitavecchia and calling at Genoa, Livorno, Marseille, Barcelona, Tangier and Saint John's and 8 more.

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At a glance

Ship: MSC Opera
Cruise line: MSC Cruises
Duration: 25 nights
Region: World Cruise
Departs: Civitavecchia
Returns: La Romana

How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact MSC Opera sailing, typically within 24 hours.

Where this voyage takes you

Voyage route — calls shown in order; map is schematic.

Day-by-day itinerary

Day
1
- Civitavecchia
  Depart 19:00
  The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
  - Gateway to Rome
  - Fort Michelangelo
  - Vatican excursions
Day
2
- Genoa
  Arrive 08:00 · Depart 18:00
  Italy's great maritime city, stacked up the Ligurian hills above one of the Mediterranean's busiest harbours. Its old town is a maze of tall, narrow caruggi, and it claims pesto and focaccia as local inventions; the Aquarium and Renaissance palaces of Via Garibaldi sit close to the port.
  - Old-town caruggi
  - Genoa Aquarium
  - Via Garibaldi palaces
Day
3
- Livorno
  Arrive 08:00 · Depart 18:00
  A Tuscan port on the Ligurian Sea and the gateway to Florence and Pisa. Ships dock here for excursions to Renaissance galleries and the Leaning Tower, while Livorno itself is known for its canal district and a seafood stew called cacciucco.
  - Gateway to Florence
  - Pisa excursions
  - Venezia Nuova canals
Day
4
- Marseille
  Arrive 09:00 · Depart 18:00
  France's oldest city and biggest Mediterranean port, set around the old harbour of the Vieux-Port. The hilltop basilica of Notre-Dame de la Garde watches over the bay, with the Calanques inlets and bouillabaisse stalls a short way off.
  - Vieux-Port
  - Notre-Dame de la Garde
  - Calanques
Day
5
- Barcelona
  Arrive 07:00 · Depart 16:00
  Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
  - Sagrada Família
  - La Rambla
  - Gothic Quarter
Day
6
At sea
Day
7
- Tangier
  Arrive 08:00 · Depart 17:00
  A Moroccan port at the mouth of the Strait of Gibraltar, where the Atlantic meets the Mediterranean and Europe lies in view across the water. Its walled medina and kasbah climb above the harbour, long a meeting point of African, Arab and European worlds.
  - The Medina
  - Kasbah
  - Strait of Gibraltar
Day
8
At sea
Day
9
At sea
Day
10
At sea
Day
11
At sea
Day
12
At sea
Day
13
At sea
Day
14
At sea
Day
15
- Saint John's
  Arrive 09:00 · Depart 18:00
  The capital of Antigua, set around a deep natural harbour in the eastern Caribbean. The island is known for its many sandy beaches and for Nelson's Dockyard, a restored Georgian naval base on the south coast that is now a World Heritage site.
  - Nelson's Dockyard
  - Dickenson Bay
  - Shirley Heights
Day
16
- Philipsburg
  Arrive 09:00 · Depart 18:00
  The Dutch-side capital of St. Maarten, set behind the long curve of Great Bay. Front Street is wall-to-wall duty-free; a short water taxi or drive reaches the French side's Marigot market and the famous low-flying jets over Maho Beach.
  - Great Bay Beach
  - Front Street duty-free
  - Maho Beach plane-spotting
Day
17
- Basseterre, Saint Kitts
  Arrive 08:00 · Depart 18:00
  The capital of St. Kitts, set below the green slopes of a volcanic Caribbean island. Its colonial centre circles The Circus and Independence Square, while the hilltop fortress of Brimstone Hill and a scenic railway lie out along the coast.
  - Brimstone Hill Fortress
  - The Circus
  - Scenic railway
Day
18
At sea
Day
19
- La Romana
  Arrive 07:00 · Depart 23:30
  A resort town on the southeast coast of the Dominican Republic, set where the Chavón river meets the Caribbean. Nearby lie the cobbled artisans' village of Altos de Chavón, the white sands of Bayahibe and boat trips to Saona island.
  - Altos de Chavón
  - Saona Island
  - Bayahibe beach
Day
20
- Catalina Island
  Arrive 07:00 · Depart 17:00
Day
21
At sea
Day
22
- Bridgetown
  Arrive 09:00 · Depart 19:00
  The capital of Barbados on the island's southwest coast, a long-standing Caribbean cruise port. Its colonial centre and Garrison Savannah are UNESCO-listed, with the white sand of Carlisle Bay and turtle-filled waters close to the harbour.
  - Carlisle Bay
  - Garrison Savannah
  - Rum distilleries
Day
23
- Fort-de-France
  Arrive 08:00 · Depart 19:00
  The capital of Martinique in the French Caribbean, set on a wide bay beneath green volcanic hills. Fort-de-France is known for the ornate Schoelcher Library, the Savane gardens by the waterfront, and views toward the Mont Pelée volcano.
  - Schoelcher Library
  - La Savane park
  - Fort Saint-Louis
Day
24
- Pointe-à-Pitre
  Arrive 07:00 · Depart 16:00
  The main town of Guadeloupe, a French overseas region in the eastern Caribbean shaped like a butterfly. It sits between the two wings of the island, with a covered spice market, Creole cooking and the volcano of La Soufrière to the south.
  - Spice market
  - La Soufrière
  - Memorial ACTe
Day
25
- Road Town, Tortola
  Arrive 07:30 · Depart 15:30
  The capital of Tortola in the British Virgin Islands, set on a harbour ringed by green hills. It is the main yachting base of the archipelago, with sheltered beaches, a small botanic garden, and ferries out to the surrounding cays.
  - Cane Garden Bay
  - Botanic Gardens
  - Yacht harbour
Day
26
- La Romana
  Arrive 09:00
  A resort town on the southeast coast of the Dominican Republic, set where the Chavón river meets the Caribbean. Nearby lie the cobbled artisans' village of Altos de Chavón, the white sands of Bayahibe and boat trips to Saona island.
  - Altos de Chavón
  - Saona Island
  - Bayahibe beach

Upcoming departures

29 Oct 2026

Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.

25-Night World Cruise Cruise from Civitavecchia FAQ

Which ports does this cruise visit?

This 25-night World Cruise cruise calls at Civitavecchia, Genoa, Livorno, Marseille, Barcelona, Tangier, Saint John's, Philipsburg, Basseterre, Saint Kitts, La Romana, Catalina Island, Bridgetown, Fort-de-France, Pointe-à-Pitre and Road Town, Tortola.

How many days are spent at sea?

10 days are spent at sea; the rest are in port.

Where does this cruise depart from?

It departs from Civitavecchia and ends in La Romana.

How long is this cruise?

25 nights aboard MSC Opera.

When does this itinerary sail?

Upcoming departures include 29 Oct 2026. A NestCruise advisor can confirm current availability.

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About: MSC Opera — 25-Night World Cruise Cruise from Civitavecchia

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