Cruise itinerary
18-Night World Cruise Cruise from Civitavecchia
18 nights · World Cruise · 10 ports of call
18-night World Cruise cruise aboard MSC Opera, departing Civitavecchia and calling at Genoa, Livorno, Marseille, Barcelona, Tangier and Saint John's and 3 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- MSC Opera
- Cruise line
- MSC Cruises
- Duration
- 18 nights
- Region
- World Cruise
- Departs
- Civitavecchia
- Returns
- La Romana
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact MSC Opera sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Civitavecchia
Depart 19:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day2
Genoa
Arrive 08:00 · Depart 18:00
Italy's great maritime city, stacked up the Ligurian hills above one of the Mediterranean's busiest harbours. Its old town is a maze of tall, narrow caruggi, and it claims pesto and focaccia as local inventions; the Aquarium and Renaissance palaces of Via Garibaldi sit close to the port.
- Old-town caruggi
- Genoa Aquarium
- Via Garibaldi palaces
- Day3
Livorno
Arrive 08:00 · Depart 18:00
A Tuscan port on the Ligurian Sea and the gateway to Florence and Pisa. Ships dock here for excursions to Renaissance galleries and the Leaning Tower, while Livorno itself is known for its canal district and a seafood stew called cacciucco.
- Gateway to Florence
- Pisa excursions
- Venezia Nuova canals
- Day4
Marseille
Arrive 09:00 · Depart 18:00
France's oldest city and biggest Mediterranean port, set around the old harbour of the Vieux-Port. The hilltop basilica of Notre-Dame de la Garde watches over the bay, with the Calanques inlets and bouillabaisse stalls a short way off.
- Vieux-Port
- Notre-Dame de la Garde
- Calanques
- Day5
Barcelona
Arrive 07:00 · Depart 16:00
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
- Day6At sea
- Day7
Tangier
Arrive 08:00 · Depart 17:00
A Moroccan port at the mouth of the Strait of Gibraltar, where the Atlantic meets the Mediterranean and Europe lies in view across the water. Its walled medina and kasbah climb above the harbour, long a meeting point of African, Arab and European worlds.
- The Medina
- Kasbah
- Strait of Gibraltar
- Day8At sea
- Day9At sea
- Day10At sea
- Day11At sea
- Day12At sea
- Day13At sea
- Day14At sea
- Day15
Saint John's
Arrive 09:00 · Depart 18:00
The capital of Antigua, set around a deep natural harbour in the eastern Caribbean. The island is known for its many sandy beaches and for Nelson's Dockyard, a restored Georgian naval base on the south coast that is now a World Heritage site.
- Nelson's Dockyard
- Dickenson Bay
- Shirley Heights
- Day16
Philipsburg
Arrive 09:00 · Depart 18:00
The Dutch-side capital of St. Maarten, set behind the long curve of Great Bay. Front Street is wall-to-wall duty-free; a short water taxi or drive reaches the French side's Marigot market and the famous low-flying jets over Maho Beach.
- Great Bay Beach
- Front Street duty-free
- Maho Beach plane-spotting
- Day17
Basseterre, Saint Kitts
Arrive 08:00 · Depart 18:00
The capital of St. Kitts, set below the green slopes of a volcanic Caribbean island. Its colonial centre circles The Circus and Independence Square, while the hilltop fortress of Brimstone Hill and a scenic railway lie out along the coast.
- Brimstone Hill Fortress
- The Circus
- Scenic railway
- Day18At sea
- Day19
La Romana
Arrive 07:00
A resort town on the southeast coast of the Dominican Republic, set where the Chavón river meets the Caribbean. Nearby lie the cobbled artisans' village of Altos de Chavón, the white sands of Bayahibe and boat trips to Saona island.
- Altos de Chavón
- Saona Island
- Bayahibe beach
Upcoming departures
- 29 Oct 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
18-Night World Cruise Cruise from Civitavecchia FAQ
Which ports does this cruise visit?
This 18-night World Cruise cruise calls at Civitavecchia, Genoa, Livorno, Marseille, Barcelona, Tangier, Saint John's, Philipsburg, Basseterre, Saint Kitts and La Romana.
How many days are spent at sea?
9 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Civitavecchia and ends in La Romana.
How long is this cruise?
18 nights aboard MSC Opera.
When does this itinerary sail?
Upcoming departures include 29 Oct 2026. A NestCruise advisor can confirm current availability.