

Cruise itinerary
41-Night South America Cruise from Fort Lauderdale, Florida
41 nights · South America · 22 ports of call
41-night South America cruise aboard Zaandam, departing Fort Lauderdale, Florida and calling at Grand Cayman, Panama Canal Transit, Panama City, Manta, Salaverry and Callao and 15 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Zaandam
- Cruise line
- Holland America Line
- Duration
- 41 nights
- Region
- South America
- Departs
- Fort Lauderdale, Florida
- Returns
- Buenos Aires
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Zaandam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1

Fort Lauderdale, Florida
Depart 19:00
A South Florida port often called the yachting capital, fringed by canals and the long sands of Fort Lauderdale Beach. Port Everglades is among the world's busiest cruise gateways, with Las Olas Boulevard's shops and cafés minutes from the piers.
- Port Everglades
- Las Olas Boulevard
- Fort Lauderdale Beach
- Day2At sea
- Day3

Grand Cayman
Arrive 08:00 · Depart 17:00
The largest of the Cayman Islands, a low coral island in the western Caribbean and a noted diving and offshore-banking centre. George Town's cruise harbour sits a short ride from Seven Mile Beach and the shallow sandbar of Stingray City.
- Seven Mile Beach
- Stingray City
- George Town
- Day4At sea
- Day5

Panama City
Arrive 20:00 · Depart 17:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
- Day6At sea
- Day7At sea
- Day8

Manta
Arrive 05:00 · Depart 20:00
- Day9At sea
- Day10

Salaverry
Arrive 08:00 · Depart 17:00
- Day11

Callao
Arrive 10:00 · Depart 18:00
Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.
- Gateway to Lima
- Miraflores
- Historic centre
- Day12At sea
- Day13

Pisco
Arrive 08:00 · Depart 17:00
- Day14At sea
- Day15At sea
- Day16

Coquimbo
Arrive 08:00 · Depart 17:00
- Day17

San Antonio
Arrive 08:00 · Depart 18:00
- Day18At sea
- Day19
Robinson Crusoe Island Chile
Arrive 08:00 · Depart 17:00
- Day20At sea
- Day21

Puerto Montt
Arrive 08:00 · Depart 17:00
A port city in Chile's Lake District, set on the Reloncaví Sound where the central valley meets the fjords of Patagonia. Snow-capped volcanoes ring the bay, and the town is a launch point for trips to lakes, the German-influenced settlement of Puerto Varas and Chiloé island.
- Osorno Volcano
- Puerto Varas
- Angelmó market
- Day22

Puerto Chacabuco
Arrive 11:00 · Depart 20:00
- Day23At sea
- Day24

Chilean Fjords
Arrive 08:00 · Depart 10:00
- Day25At sea
- Day26

Punta Arenas
Arrive 07:00 · Depart 20:00
A windswept city on the Strait of Magellan in Chilean Patagonia, one of the southernmost ports on earth. It serves as a gateway to Tierra del Fuego, Antarctic crossings and nearby penguin colonies, with a grand central plaza recalling the wool and shipping boom.
- Strait of Magellan
- Plaza de Armas
- Penguin colonies
- Day27

Cape Horn
- Day28

Ushuaia
Arrive 06:00 · Depart 18:00
The world's southernmost city, on Argentina's Tierra del Fuego at the tip of South America. Backed by snowy peaks on the Beagle Channel, it is the chief departure port for Antarctica and a base for the Patagonian wilderness.
- Beagle Channel
- Tierra del Fuego park
- End of the world
- Day29At sea
- Day30At sea
- Day31At sea
- Day32At sea
- Day33At sea
- Day34At sea
- Day35

Port Stanley
Arrive 08:00 · Depart 17:00
The small capital of the Falkland Islands in the South Atlantic, a row of brightly painted houses and tin roofs along a sheltered harbour. Penguin colonies and windswept moorland surround the settlement, with Christ Church Cathedral and its whalebone arch at the waterfront.
- Penguin colonies
- Whalebone Arch
- Christ Church Cathedral
- Day36At sea
- Day37

Puerto Madryn
Arrive 08:00 · Depart 17:00
A Patagonian port on the Gulf of Nuevo in Argentine coastal Chubut, founded by Welsh settlers. It is the gateway to the Península Valdés nature reserve, where southern right whales, sea lions and penguins gather along the coast.
- Península Valdés
- Whale watching
- Welsh heritage
- Day38At sea
- Day39

Punta del Este
Arrive 10:00 · Depart 18:00
- Day40

Montevideo
Arrive 08:00 · Depart 18:00
The capital of Uruguay, set on the north bank of the broad Río de la Plata. Its old town keeps colonial plazas and a long riverside promenade, the Rambla, in a relaxed South American port city known for grilled meat and mate.
- Ciudad Vieja
- The Rambla
- Plaza Independencia
- Day41At sea
- Day42

Buenos Aires
Arrive 08:00
Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
- La Boca
- San Telmo
- Tango culture
Upcoming departures
- 3 Jan 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
41-Night South America Cruise from Fort Lauderdale, Florida FAQ
Which ports does this cruise visit?
This 41-night South America cruise calls at Fort Lauderdale, Florida, Grand Cayman, Panama Canal Transit, Panama City, Manta, Salaverry, Callao, Pisco, Coquimbo, San Antonio, Robinson Crusoe Island Chile, Puerto Montt, Puerto Chacabuco, Chilean Fjords, Punta Arenas, Cape Horn, Ushuaia, Port Stanley, Puerto Madryn, Punta del Este, Montevideo and Buenos Aires.
How many days are spent at sea?
21 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Fort Lauderdale, Florida and ends in Buenos Aires.
How long is this cruise?
41 nights aboard Zaandam.
When does this itinerary sail?
Upcoming departures include 3 Jan 2027. A NestCruise advisor can confirm current availability.