

Cruise itinerary
22-Night Americas Cruise from San Antonio
22 nights · Americas · 10 ports of call
22-night Americas cruise aboard Oosterdam, departing San Antonio and calling at Puerto Montt, Puerto Chacabuco, Punta Arenas, Ushuaia, Cape Horn and Antarctic Experience and 3 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oosterdam
- Cruise line
- Holland America Line
- Duration
- 22 nights
- Region
- Americas · Polar · Antarctica · South America
- Departs
- San Antonio
- Returns
- Buenos Aires
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oosterdam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1

San Antonio
Depart 18:00
- Day2At sea
- Day3

Puerto Montt
Arrive 08:00 · Depart 17:00
A port city in Chile's Lake District, set on the Reloncaví Sound where the central valley meets the fjords of Patagonia. Snow-capped volcanoes ring the bay, and the town is a launch point for trips to lakes, the German-influenced settlement of Puerto Varas and Chiloé island.
- Osorno Volcano
- Puerto Varas
- Angelmó market
- Day4

Puerto Chacabuco
Arrive 10:00 · Depart 18:00
- Day5At sea
- Day6At sea
- Day7

Punta Arenas
Arrive 06:00 · Depart 18:00
A windswept city on the Strait of Magellan in Chilean Patagonia, one of the southernmost ports on earth. It serves as a gateway to Tierra del Fuego, Antarctic crossings and nearby penguin colonies, with a grand central plaza recalling the wool and shipping boom.
- Strait of Magellan
- Plaza de Armas
- Penguin colonies
- Day8

Ushuaia
Arrive 14:00 · Depart 20:00
The world's southernmost city, on Argentina's Tierra del Fuego at the tip of South America. Backed by snowy peaks on the Beagle Channel, it is the chief departure port for Antarctica and a base for the Patagonian wilderness.
- Beagle Channel
- Tierra del Fuego park
- End of the world
- Day9

Cape Horn
- Day10At sea
- Day11

Antarctic Experience
Arrive 08:00 · Depart 18:00
A scenic-cruising day among the icebergs and channels of the Antarctic Peninsula, the planet's southernmost wilderness. Ships glide past glaciers and tabular bergs, with whales, seals and vast penguin colonies often visible from deck.
- Penguin colonies
- Glaciers and icebergs
- Whale watching
- Day12

Antarctic Experience
Arrive 08:00 · Depart 18:00
A scenic-cruising day among the icebergs and channels of the Antarctic Peninsula, the planet's southernmost wilderness. Ships glide past glaciers and tabular bergs, with whales, seals and vast penguin colonies often visible from deck.
- Penguin colonies
- Glaciers and icebergs
- Whale watching
- Day13

Antarctic Experience
Arrive 08:00 · Depart 18:00
A scenic-cruising day among the icebergs and channels of the Antarctic Peninsula, the planet's southernmost wilderness. Ships glide past glaciers and tabular bergs, with whales, seals and vast penguin colonies often visible from deck.
- Penguin colonies
- Glaciers and icebergs
- Whale watching
- Day14

Antarctic Experience
Arrive 08:00 · Depart 18:00
A scenic-cruising day among the icebergs and channels of the Antarctic Peninsula, the planet's southernmost wilderness. Ships glide past glaciers and tabular bergs, with whales, seals and vast penguin colonies often visible from deck.
- Penguin colonies
- Glaciers and icebergs
- Whale watching
- Day15

Antarctic Experience
Arrive 08:00 · Depart 18:00
A scenic-cruising day among the icebergs and channels of the Antarctic Peninsula, the planet's southernmost wilderness. Ships glide past glaciers and tabular bergs, with whales, seals and vast penguin colonies often visible from deck.
- Penguin colonies
- Glaciers and icebergs
- Whale watching
- Day16At sea
- Day17

Port Stanley
Arrive 08:00 · Depart 17:00
The small capital of the Falkland Islands in the South Atlantic, a row of brightly painted houses and tin roofs along a sheltered harbour. Penguin colonies and windswept moorland surround the settlement, with Christ Church Cathedral and its whalebone arch at the waterfront.
- Penguin colonies
- Whalebone Arch
- Christ Church Cathedral
- Day18At sea
- Day19At sea
- Day20

Montevideo
Arrive 08:00
The capital of Uruguay, set on the north bank of the broad Río de la Plata. Its old town keeps colonial plazas and a long riverside promenade, the Rambla, in a relaxed South American port city known for grilled meat and mate.
- Ciudad Vieja
- The Rambla
- Plaza Independencia
- Day21

Montevideo
Depart 18:00
The capital of Uruguay, set on the north bank of the broad Río de la Plata. Its old town keeps colonial plazas and a long riverside promenade, the Rambla, in a relaxed South American port city known for grilled meat and mate.
- Ciudad Vieja
- The Rambla
- Plaza Independencia
- Day22

Buenos Aires
Arrive 08:00
Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
- La Boca
- San Telmo
- Tango culture
- Day23

Buenos Aires
Arrive 06:00
Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
- La Boca
- San Telmo
- Tango culture
Upcoming departures
- 10 Jan 2027
- 1 Feb 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
22-Night Americas Cruise from San Antonio FAQ
Which ports does this cruise visit?
This 22-night Americas cruise calls at San Antonio, Puerto Montt, Puerto Chacabuco, Punta Arenas, Ushuaia, Cape Horn, Antarctic Experience, Port Stanley, Montevideo and Buenos Aires.
How many days are spent at sea?
7 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from San Antonio and ends in Buenos Aires.
How long is this cruise?
22 nights aboard Oosterdam.
When does this itinerary sail?
Upcoming departures include 10 Jan 2027 and 1 Feb 2027. A NestCruise advisor can confirm current availability.