Cruise itinerary
21-Night Europe Cruise from Trieste
21 nights · Europe · 12 ports of call
21-night Europe cruise aboard Oosterdam, departing Trieste and calling at Split, Dubrovnik, Santorini, Mykonos, Kos and Kusadasi and 5 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oosterdam
- Cruise line
- Holland America Line
- Duration
- 21 nights
- Region
- Europe · Southern Europe · Mediterranean
- Departs
- Trieste
- Returns
- Civitavecchia
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oosterdam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Trieste
Depart 17:00
A port city in northeast Italy near the Slovenian border, long the seaward gateway of the Austro-Hungarian Empire. Grand Habsburg-era squares open onto the Adriatic, with the seafront Piazza Unità d'Italia and the white Miramare Castle on the bay.
- Piazza Unità d'Italia
- Miramare Castle
- Viennese cafés
- Day2
Split
Arrive 08:00 · Depart 17:00
A Croatian port on the Dalmatian coast, built quite literally inside the walls of a Roman emperor's retirement palace. Diocletian's Palace still forms the living old town, its cellars and courtyards woven through with cafes, shops and the cathedral.
- Diocletian's Palace
- Riva promenade
- Marjan Hill
- Day3
Dubrovnik
Arrive 08:00 · Depart 17:00
A walled city on Croatia's Dalmatian coast, its limestone old town wrapped in sea-facing ramparts above the Adriatic. Ships call here for the marble main street of Stradun, the circuit of the city walls and the cable car to Mount Srđ.
- City walls
- Stradun
- Mount Srđ cable car
- Day4At sea
- Day5
Santorini
Arrive 08:00 · Depart 19:00
The crescent rim of a flooded volcanic caldera in the Greek Cyclades, its whitewashed villages strung along cliffs high above the sea. Fira and Oia draw crowds for sunset views, while the caldera's dark beaches and the ancient site of Akrotiri lie below.
- Oia sunset
- Fira town
- Caldera cliffs
- Day6
Mykonos
Arrive 07:00 · Depart 18:00
A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
- Windmills
- Little Venice
- Chora town
- Day7
Kos
Arrive 08:00 · Depart 17:00
- Day8
Kusadasi
Arrive 07:00 · Depart 16:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day9
Istanbul
Arrive 12:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day10
Istanbul
Depart 19:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day11At sea
- Day12
Piraeus
Arrive 07:00 · Depart 17:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day13
Mykonos
Arrive 07:00 · Depart 20:00
A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
- Windmills
- Little Venice
- Chora town
- Day14At sea
- Day15
Istanbul
Arrive 07:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day16
Istanbul
Depart 17:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day17At sea
- Day18
Santorini
Arrive 08:00 · Depart 17:00
The crescent rim of a flooded volcanic caldera in the Greek Cyclades, its whitewashed villages strung along cliffs high above the sea. Fira and Oia draw crowds for sunset views, while the caldera's dark beaches and the ancient site of Akrotiri lie below.
- Oia sunset
- Fira town
- Caldera cliffs
- Day19
Khania
Arrive 08:00 · Depart 18:00
A harbour town on the northwest coast of Crete, in Greece, wrapped around a Venetian port. A waterfront lighthouse marks the old harbour mouth, and the pink-sand lagoon of Balos and the beach at Elafonisi lie along the coast to the west.
- Venetian harbour
- Balos lagoon
- Elafonisi beach
- Day20At sea
- Day21
Messina
Arrive 07:00 · Depart 13:00
A Sicilian port on the strait that separates the island from mainland Italy, framed by the Peloritani mountains. Its harbour clock tower performs an elaborate noon display, and the town is a common gateway to Taormina and the slopes of Mount Etna.
- Etna day trips
- Taormina gateway
- Astronomical clock
- Day22
Civitavecchia
Arrive 07:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
Upcoming departures
- 21 Sep 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
21-Night Europe Cruise from Trieste FAQ
Which ports does this cruise visit?
This 21-night Europe cruise calls at Trieste, Split, Dubrovnik, Santorini, Mykonos, Kos, Kusadasi, Istanbul, Piraeus, Khania, Messina and Civitavecchia.
How many days are spent at sea?
5 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Trieste and ends in Civitavecchia.
How long is this cruise?
21 nights aboard Oosterdam.
When does this itinerary sail?
Upcoming departures include 21 Sep 2027. A NestCruise advisor can confirm current availability.