Cruise itinerary
21-Night Mediterranean Cruise from Civitavecchia
21 nights · Mediterranean · 12 ports of call
21-night Mediterranean cruise aboard Oosterdam, departing Civitavecchia and calling at Salerno, Palermo, Cagliari, Palma de Mallorca, Alicante and Gibraltar and 5 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oosterdam
- Cruise line
- Holland America Line
- Duration
- 21 nights
- Region
- Mediterranean
- Departs
- Civitavecchia
- Returns
- Civitavecchia
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oosterdam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Civitavecchia
Depart 17:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day2
Salerno
Arrive 07:00 · Depart 17:00
An Italian port at the head of its own gulf, just south of the Amalfi Coast. Its long seafront and walkable medieval centre make it a quieter base for reaching Pompeii, Paestum's Greek temples and the cliffside towns of Amalfi and Positano.
- Amalfi Coast gateway
- Paestum temples
- Seafront promenade
- Day3
Palermo
Arrive 07:00 · Depart 17:00
The capital of Sicily, a port city layered with Arab, Norman, and Baroque history on the island's north coast. Palermo is known for its mosaic-rich Cappella Palatina, lively street-food markets, and the Norman cathedral at nearby Monreale.
- Cappella Palatina
- Ballarò market
- Monreale mosaics
- Day4
Cagliari
Arrive 08:00 · Depart 17:00
The capital of Sardinia, an Italian port set across hills above the Gulf of the Angels. Its fortified Castello quarter looks down over the harbour, with a long city beach at Poetto and the Roman amphitheatre among its older landmarks.
- Castello quarter
- Poetto Beach
- Roman amphitheatre
- Day5At sea
- Day6
Palma de Mallorca
Arrive 07:00 · Depart 17:00
The capital of Mallorca in Spain's Balearic Islands, set around a wide bay. Its enormous seafront cathedral, La Seu, rises above the old town's narrow lanes, with a hilltop castle, marina and nearby coves a short way from the cruise terminal.
- La Seu cathedral
- Bellver Castle
- Old town
- Day7
Alicante
Arrive 08:00 · Depart 20:00
A sun-warmed port on Spain's Costa Blanca, set below the Santa Bárbara castle on its rocky headland. The palm-lined Explanada promenade leads to a long city beach, with the old Barrio Santa Cruz climbing the hill in white houses.
- Santa Bárbara Castle
- Explanada promenade
- Postiguet Beach
- Day8At sea
- Day9
Gibraltar
Arrive 07:00 · Depart 18:00
A British territory at the southern tip of Spain, dominated by its towering limestone Rock. Cable cars climb to the summit, home to Europe's only wild monkeys, with sweeping views across the strait toward the coast of Africa.
- The Rock
- Barbary macaques
- St. Michael's Cave
- Day10
Cádiz
Arrive 07:00 · Depart 15:00
One of the oldest continuously inhabited cities in Western Europe, set on a narrow spit almost surrounded by the Atlantic in Spain's Andalusia. A gold-domed cathedral rises over the old town's tight lanes, sea walls and the long sands of La Caleta.
- Cádiz Cathedral
- La Caleta beach
- Old town lanes
- Day11
Lisbon
Arrive 07:00 · Depart 17:00
Portugal's hilly capital, spread across seven hills above the Tagus estuary. Yellow trams climb to the Alfama's tangled lanes and the Castle of São Jorge, while Belém's monastery and pastéis de nata anchor the riverside to the west.
- Alfama district
- Belém Tower
- Tram 28
- Day12
Cádiz
Arrive 11:00 · Depart 21:00
One of the oldest continuously inhabited cities in Western Europe, set on a narrow spit almost surrounded by the Atlantic in Spain's Andalusia. A gold-domed cathedral rises over the old town's tight lanes, sea walls and the long sands of La Caleta.
- Cádiz Cathedral
- La Caleta beach
- Old town lanes
- Day13
Tangier
Arrive 07:00 · Depart 16:00
A Moroccan port at the mouth of the Strait of Gibraltar, where the Atlantic meets the Mediterranean and Europe lies in view across the water. Its walled medina and kasbah climb above the harbour, long a meeting point of African, Arab and European worlds.
- The Medina
- Kasbah
- Strait of Gibraltar
- Day14At sea
- Day15
Valencia
Arrive 07:00 · Depart 17:00
Spain's third city, on the Mediterranean coast where the old riverbed has become a long ribbon of parkland. It is the birthplace of paella, home to the silk-era Lonja trading hall and to Calatrava's white City of Arts and Sciences complex.
- City of Arts and Sciences
- La Lonja
- Paella
- Day16At sea
- Day17
Valletta
Arrive 13:00 · Depart 20:00
Malta's fortified harbour capital, built by the Knights of St. John on a peninsula between two deep ports. Honey-coloured limestone defines St. John's Co-Cathedral, the Grand Master's Palace and the bastions overlooking the Grand Harbour.
- Grand Harbour
- St. John's Co-Cathedral
- Upper Barrakka Gardens
- Day18At sea
- Day19At sea
- Day20
Salerno
Arrive 07:00 · Depart 16:00
An Italian port at the head of its own gulf, just south of the Amalfi Coast. Its long seafront and walkable medieval centre make it a quieter base for reaching Pompeii, Paestum's Greek temples and the cliffside towns of Amalfi and Positano.
- Amalfi Coast gateway
- Paestum temples
- Seafront promenade
- Day21
Civitavecchia
Arrive 04:30 · Depart 04:30
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day22
Civitavecchia
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
Upcoming departures
- 24 May 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
21-Night Mediterranean Cruise from Civitavecchia FAQ
Which ports does this cruise visit?
This 21-night Mediterranean cruise calls at Civitavecchia, Salerno, Palermo, Cagliari, Palma de Mallorca, Alicante, Gibraltar, Cádiz, Lisbon, Tangier, Valencia and Valletta.
How many days are spent at sea?
6 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from Civitavecchia.
How long is this cruise?
21 nights aboard Oosterdam.
When does this itinerary sail?
Upcoming departures include 24 May 2026. A NestCruise advisor can confirm current availability.