Cruise itinerary
21-Night Greek Islands Cruise from Piraeus
21 nights · Greek Islands · 10 ports of call
21-night Greek Islands cruise aboard Oosterdam, departing Piraeus and calling at Alexandria, Haifa, Limassol, Antalya, Rhodes and Kusadasi and 3 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oosterdam
- Cruise line
- Holland America Line
- Duration
- 21 nights
- Region
- Greek Islands
- Departs
- Piraeus
- Returns
- Piraeus
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oosterdam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Piraeus
Depart 17:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day2At sea
- Day3
Alexandria
Arrive 07:00 · Depart 23:59
Egypt's great Mediterranean port, founded by Alexander the Great. Once home to the ancient Lighthouse and Library, it keeps a long seafront corniche, the Qaitbay citadel on the old harbour and the modern Bibliotheca Alexandrina library.
- Qaitbay Citadel
- Bibliotheca Alexandrina
- Corniche seafront
- Day4At sea
- Day5
Haifa
Arrive 08:00 · Depart 21:00
- Day6At sea
- Day7
Limassol
Arrive 08:00 · Depart 17:00
A southern coastal city on Cyprus in the eastern Mediterranean, set around a long seafront promenade. A medieval castle anchors the old town, and the port is a base for the ancient ruins of Kourion and the wine villages of the Troodos foothills.
- Limassol Castle
- Kourion ruins
- seafront promenade
- Day8
Antalya
Arrive 08:00 · Depart 17:00
- Day9
Rhodes
Arrive 08:00 · Depart 23:00
The largest of Greece's Dodecanese islands, off the Turkish coast, with one of Europe's best-preserved medieval walled towns. The Old Town keeps the cobbled Street of the Knights and the Palace of the Grand Master, while Lindos and its acropolis lie down the coast.
- Medieval Old Town
- Palace of the Grand Master
- Lindos Acropolis
- Day10At sea
- Day11
Kusadasi
Arrive 07:00 · Depart 19:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day12
Piraeus
Arrive 07:00 · Depart 17:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day13
Mykonos
Arrive 07:00 · Depart 20:00
A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
- Windmills
- Little Venice
- Chora town
- Day14At sea
- Day15
Istanbul
Arrive 07:00 · Depart 23:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day16At sea
- Day17At sea
- Day18
Kusadasi
Arrive 07:00 · Depart 19:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day19
Kos
Arrive 08:00 · Depart 18:00
- Day20
Rhodes
Arrive 08:00 · Depart 21:00
The largest of Greece's Dodecanese islands, off the Turkish coast, with one of Europe's best-preserved medieval walled towns. The Old Town keeps the cobbled Street of the Knights and the Palace of the Grand Master, while Lindos and its acropolis lie down the coast.
- Medieval Old Town
- Palace of the Grand Master
- Lindos Acropolis
- Day21At sea
- Day22
Piraeus
Arrive 07:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
Upcoming departures
- 3 Oct 2026
- 2 Oct 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
21-Night Greek Islands Cruise from Piraeus FAQ
Which ports does this cruise visit?
This 21-night Greek Islands cruise calls at Piraeus, Alexandria, Haifa, Limassol, Antalya, Rhodes, Kusadasi, Mykonos, Istanbul and Kos.
How many days are spent at sea?
8 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from Piraeus.
How long is this cruise?
21 nights aboard Oosterdam.
When does this itinerary sail?
Upcoming departures include 3 Oct 2026 and 2 Oct 2027. A NestCruise advisor can confirm current availability.