Cruise itinerary
16-Night South America Cruise from San Antonio
16 nights · South America · 10 ports of call
16-night South America cruise aboard Oosterdam, departing San Antonio and calling at Coquimbo, Pisco, Callao, Salaverry, Manta and Panama City and 3 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oosterdam
- Cruise line
- Holland America Line
- Duration
- 16 nights
- Region
- South America
- Departs
- San Antonio
- Returns
- Fort Lauderdale, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oosterdam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
San Antonio
Depart 17:00
- Day2
Coquimbo
Arrive 08:00 · Depart 16:00
- Day3At sea
- Day4At sea
- Day5
Pisco
Arrive 08:00 · Depart 18:00
- Day6
Callao
Arrive 06:00 · Depart 14:00
Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.
- Gateway to Lima
- Miraflores
- Historic centre
- Day7At sea
- Day8
Salaverry
Arrive 08:00 · Depart 17:00
- Day9At sea
- Day10
Manta
Arrive 05:00 · Depart 19:00
- Day11At sea
- Day12
Panama City
Arrive 10:00 · Depart 05:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
- Day13
Panama Canal Transit
- Day14At sea
- Day15
Grand Cayman
Arrive 08:00 · Depart 15:00
The largest of the Cayman Islands, a low coral island in the western Caribbean and a noted diving and offshore-banking centre. George Town's cruise harbour sits a short ride from Seven Mile Beach and the shallow sandbar of Stingray City.
- Seven Mile Beach
- Stingray City
- George Town
- Day16At sea
- Day17
Fort Lauderdale, Florida
Arrive 07:00
A South Florida port often called the yachting capital, fringed by canals and the long sands of Fort Lauderdale Beach. Port Everglades is among the world's busiest cruise gateways, with Las Olas Boulevard's shops and cafés minutes from the piers.
- Port Everglades
- Las Olas Boulevard
- Fort Lauderdale Beach
Upcoming departures
- 24 Mar 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
16-Night South America Cruise from San Antonio FAQ
Which ports does this cruise visit?
This 16-night South America cruise calls at San Antonio, Coquimbo, Pisco, Callao, Salaverry, Manta, Panama City, Panama Canal Transit, Grand Cayman and Fort Lauderdale, Florida.
How many days are spent at sea?
7 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from San Antonio and ends in Fort Lauderdale, Florida.
How long is this cruise?
16 nights aboard Oosterdam.
When does this itinerary sail?
Upcoming departures include 24 Mar 2027. A NestCruise advisor can confirm current availability.