Cruise itinerary
16-Night South America Cruise from Fort Lauderdale, Florida
16 nights · South America · 10 ports of call
16-night South America cruise aboard Oosterdam, departing Fort Lauderdale, Florida and calling at Grand Cayman, Panama Canal Transit, Panama City, Manta, Salaverry and Callao and 3 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oosterdam
- Cruise line
- Holland America Line
- Duration
- 16 nights
- Region
- South America
- Departs
- Fort Lauderdale, Florida
- Returns
- San Antonio
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oosterdam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Fort Lauderdale, Florida
Depart 17:00
A South Florida port often called the yachting capital, fringed by canals and the long sands of Fort Lauderdale Beach. Port Everglades is among the world's busiest cruise gateways, with Las Olas Boulevard's shops and cafés minutes from the piers.
- Port Everglades
- Las Olas Boulevard
- Fort Lauderdale Beach
- Day2At sea
- Day3
Grand Cayman
Arrive 10:00 · Depart 18:00
The largest of the Cayman Islands, a low coral island in the western Caribbean and a noted diving and offshore-banking centre. George Town's cruise harbour sits a short ride from Seven Mile Beach and the shallow sandbar of Stingray City.
- Seven Mile Beach
- Stingray City
- George Town
- Day4At sea
- Day5
Panama City
Arrive 21:00 · Depart 16:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
- Day6At sea
- Day7At sea
- Day8
Manta
Arrive 06:00 · Depart 20:00
- Day9At sea
- Day10
Salaverry
Arrive 08:00 · Depart 17:00
- Day11
Callao
Arrive 10:00 · Depart 18:00
Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.
- Gateway to Lima
- Miraflores
- Historic centre
- Day12At sea
- Day13
Pisco
Arrive 07:00 · Depart 18:00
- Day14At sea
- Day15At sea
- Day16
Coquimbo
Arrive 08:00 · Depart 16:00
- Day17
San Antonio
Arrive 07:00
Upcoming departures
- 18 Nov 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
16-Night South America Cruise from Fort Lauderdale, Florida FAQ
Which ports does this cruise visit?
This 16-night South America cruise calls at Fort Lauderdale, Florida, Grand Cayman, Panama Canal Transit, Panama City, Manta, Salaverry, Callao, Pisco, Coquimbo and San Antonio.
How many days are spent at sea?
8 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Fort Lauderdale, Florida and ends in San Antonio.
How long is this cruise?
16 nights aboard Oosterdam.
When does this itinerary sail?
Upcoming departures include 18 Nov 2026. A NestCruise advisor can confirm current availability.