

Cruise itinerary
26-Night South America Cruise from Vancouver, British Columbia
26 nights · South America · 14 ports of call
26-night South America cruise aboard Nieuw Amsterdam, departing Vancouver, British Columbia and calling at San Francisco, California, San Diego, California, Cabo San Lucas, Huatulco (Santa María Huatulco), Puerto Quetzal and Puntarenas and 7 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Nieuw Amsterdam
- Cruise line
- Holland America Line
- Duration
- 26 nights
- Region
- South America
- Departs
- Vancouver, British Columbia
- Returns
- San Antonio
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Nieuw Amsterdam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1

Vancouver, British Columbia
Depart 17:00
A Pacific coast city in British Columbia and the main homeport for Alaska cruises. Ships sail from beneath the sails of Canada Place, with Stanley Park's seawall, the totem poles and the cobbled Gastown district close to the terminal.
- Stanley Park
- Gastown
- Gateway to Alaska
- Day2At sea
- Day3At sea
- Day4

San Francisco, California
Arrive 08:00 · Depart 21:00
A hill-built city on a peninsula between the Pacific and San Francisco Bay, known for the Golden Gate Bridge, cable cars, and Victorian rowhouses. Ships dock near the Embarcadero, within reach of Fisherman's Wharf, Chinatown, and ferries to Alcatraz.
- Golden Gate Bridge
- Cable cars
- Alcatraz Island
- Day5At sea
- Day6

San Diego, California
Arrive 07:00 · Depart 17:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day7At sea
- Day8

Cabo San Lucas
Arrive 11:00 · Depart 18:00
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day9At sea
- Day10At sea
- Day11

Huatulco (Santa María Huatulco)
Arrive 07:00 · Depart 14:00
- Day12

Puerto Quetzal
Arrive 10:00 · Depart 20:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day13At sea
- Day14

Puntarenas
Arrive 08:00 · Depart 17:00
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day15At sea
- Day16

Manta
Arrive 12:00 · Depart 18:00
- Day17At sea
- Day18At sea
- Day19

Salaverry
Arrive 07:00 · Depart 16:00
- Day20

Callao
Arrive 10:00 · Depart 20:00
Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.
- Gateway to Lima
- Miraflores
- Historic centre
- Day21At sea
- Day22

Pisco
Arrive 07:00 · Depart 18:00
- Day23At sea
- Day24

Arica
Arrive 08:00 · Depart 17:00
- Day25At sea
- Day26

Coquimbo
Arrive 08:00 · Depart 16:00
- Day27

San Antonio
Arrive 07:00
Upcoming departures
- 7 Oct 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
26-Night South America Cruise from Vancouver, British Columbia FAQ
Which ports does this cruise visit?
This 26-night South America cruise calls at Vancouver, British Columbia, San Francisco, California, San Diego, California, Cabo San Lucas, Huatulco (Santa María Huatulco), Puerto Quetzal, Puntarenas, Manta, Salaverry, Callao, Pisco, Arica, Coquimbo and San Antonio.
How many days are spent at sea?
13 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Vancouver, British Columbia and ends in San Antonio.
How long is this cruise?
26 nights aboard Nieuw Amsterdam.
When does this itinerary sail?
Upcoming departures include 7 Oct 2027. A NestCruise advisor can confirm current availability.