Cruise itinerary
22-Night South America Cruise from San Antonio
22 nights · South America · 11 ports of call
22-night South America cruise aboard Nieuw Amsterdam, departing San Antonio and calling at Puerto Montt, Puerto Chacabuco, Punta Arenas, Ushuaia, Cape Horn and Port Stanley and 4 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Nieuw Amsterdam
- Cruise line
- Holland America Line
- Duration
- 22 nights
- Region
- South America
- Departs
- San Antonio
- Returns
- Buenos Aires
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Nieuw Amsterdam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
San Antonio
Depart 18:00
- Day2At sea
- Day3
Puerto Montt
Arrive 08:00 · Depart 17:00
A port city in Chile's Lake District, set on the Reloncaví Sound where the central valley meets the fjords of Patagonia. Snow-capped volcanoes ring the bay, and the town is a launch point for trips to lakes, the German-influenced settlement of Puerto Varas and Chiloé island.
- Osorno Volcano
- Puerto Varas
- Angelmó market
- Day4
Puerto Chacabuco
Arrive 10:00 · Depart 18:00
- Day5At sea
- Day6At sea
- Day7
Punta Arenas
Arrive 06:00 · Depart 18:00
A windswept city on the Strait of Magellan in Chilean Patagonia, one of the southernmost ports on earth. It serves as a gateway to Tierra del Fuego, Antarctic crossings and nearby penguin colonies, with a grand central plaza recalling the wool and shipping boom.
- Strait of Magellan
- Plaza de Armas
- Penguin colonies
- Day8
Ushuaia
Arrive 14:00 · Depart 20:00
The world's southernmost city, on Argentina's Tierra del Fuego at the tip of South America. Backed by snowy peaks on the Beagle Channel, it is the chief departure port for Antarctica and a base for the Patagonian wilderness.
- Beagle Channel
- Tierra del Fuego park
- End of the world
- Day9
Cape Horn
- Day10At sea
- Day11At sea
- Day12At sea
- Day13At sea
- Day14At sea
- Day15At sea
- Day16
Port Stanley
Arrive 08:00 · Depart 17:00
The small capital of the Falkland Islands in the South Atlantic, a row of brightly painted houses and tin roofs along a sheltered harbour. Penguin colonies and windswept moorland surround the settlement, with Christ Church Cathedral and its whalebone arch at the waterfront.
- Penguin colonies
- Whalebone Arch
- Christ Church Cathedral
- Day17At sea
- Day18
Puerto Madryn
Arrive 08:00 · Depart 17:00
A Patagonian port on the Gulf of Nuevo in Argentine coastal Chubut, founded by Welsh settlers. It is the gateway to the Península Valdés nature reserve, where southern right whales, sea lions and penguins gather along the coast.
- Península Valdés
- Whale watching
- Welsh heritage
- Day19At sea
- Day20
Punta del Este
Arrive 10:00 · Depart 19:00
- Day21
Montevideo
Arrive 07:00 · Depart 18:00
The capital of Uruguay, set on the north bank of the broad Río de la Plata. Its old town keeps colonial plazas and a long riverside promenade, the Rambla, in a relaxed South American port city known for grilled meat and mate.
- Ciudad Vieja
- The Rambla
- Plaza Independencia
- Day22
Buenos Aires
Arrive 08:00 · Depart 08:00
Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
- La Boca
- San Telmo
- Tango culture
- Day23
Buenos Aires
Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
- La Boca
- San Telmo
- Tango culture
Upcoming departures
- 8 Jan 2028
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
22-Night South America Cruise from San Antonio FAQ
Which ports does this cruise visit?
This 22-night South America cruise calls at San Antonio, Puerto Montt, Puerto Chacabuco, Punta Arenas, Ushuaia, Cape Horn, Port Stanley, Puerto Madryn, Punta del Este, Montevideo and Buenos Aires.
How many days are spent at sea?
11 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from San Antonio and ends in Buenos Aires.
How long is this cruise?
22 nights aboard Nieuw Amsterdam.
When does this itinerary sail?
Upcoming departures include 8 Jan 2028. A NestCruise advisor can confirm current availability.