Cruise itinerary
22-Night South America Cruise from Buenos Aires
22 nights · South America · 10 ports of call
22-night South America cruise aboard Nieuw Amsterdam, departing Buenos Aires and calling at Montevideo, Puerto Madryn, Port Stanley, Cape Horn, Ushuaia and Punta Arenas and 3 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Nieuw Amsterdam
- Cruise line
- Holland America Line
- Duration
- 22 nights
- Region
- South America
- Departs
- Buenos Aires
- Returns
- San Antonio
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Nieuw Amsterdam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Buenos Aires
Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
- La Boca
- San Telmo
- Tango culture
- Day2
Buenos Aires
Arrive 18:00 · Depart 18:00
Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
- La Boca
- San Telmo
- Tango culture
- Day3
Montevideo
Arrive 08:00 · Depart 15:00
The capital of Uruguay, set on the north bank of the broad Río de la Plata. Its old town keeps colonial plazas and a long riverside promenade, the Rambla, in a relaxed South American port city known for grilled meat and mate.
- Ciudad Vieja
- The Rambla
- Plaza Independencia
- Day4At sea
- Day5At sea
- Day6
Puerto Madryn
Arrive 09:00 · Depart 17:00
A Patagonian port on the Gulf of Nuevo in Argentine coastal Chubut, founded by Welsh settlers. It is the gateway to the Península Valdés nature reserve, where southern right whales, sea lions and penguins gather along the coast.
- Península Valdés
- Whale watching
- Welsh heritage
- Day7At sea
- Day8
Port Stanley
Arrive 08:00 · Depart 17:00
The small capital of the Falkland Islands in the South Atlantic, a row of brightly painted houses and tin roofs along a sheltered harbour. Penguin colonies and windswept moorland surround the settlement, with Christ Church Cathedral and its whalebone arch at the waterfront.
- Penguin colonies
- Whalebone Arch
- Christ Church Cathedral
- Day9At sea
- Day10At sea
- Day11At sea
- Day12At sea
- Day13At sea
- Day14At sea
- Day15
Cape Horn
- Day16
Ushuaia
Arrive 09:00 · Depart 15:30
The world's southernmost city, on Argentina's Tierra del Fuego at the tip of South America. Backed by snowy peaks on the Beagle Channel, it is the chief departure port for Antarctica and a base for the Patagonian wilderness.
- Beagle Channel
- Tierra del Fuego park
- End of the world
- Day17
Punta Arenas
Arrive 10:00 · Depart 22:00
A windswept city on the Strait of Magellan in Chilean Patagonia, one of the southernmost ports on earth. It serves as a gateway to Tierra del Fuego, Antarctic crossings and nearby penguin colonies, with a grand central plaza recalling the wool and shipping boom.
- Strait of Magellan
- Plaza de Armas
- Penguin colonies
- Day18At sea
- Day19At sea
- Day20
Puerto Chacabuco
Arrive 07:00 · Depart 15:00
- Day21
Puerto Montt
Arrive 08:00 · Depart 17:00
A port city in Chile's Lake District, set on the Reloncaví Sound where the central valley meets the fjords of Patagonia. Snow-capped volcanoes ring the bay, and the town is a launch point for trips to lakes, the German-influenced settlement of Puerto Varas and Chiloé island.
- Osorno Volcano
- Puerto Varas
- Angelmó market
- Day22At sea
- Day23
San Antonio
Arrive 07:00
Upcoming departures
- 17 Dec 2027
- 30 Jan 2028
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
22-Night South America Cruise from Buenos Aires FAQ
Which ports does this cruise visit?
This 22-night South America cruise calls at Buenos Aires, Montevideo, Puerto Madryn, Port Stanley, Cape Horn, Ushuaia, Punta Arenas, Puerto Chacabuco, Puerto Montt and San Antonio.
How many days are spent at sea?
12 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Buenos Aires and ends in San Antonio.
How long is this cruise?
22 nights aboard Nieuw Amsterdam.
When does this itinerary sail?
Upcoming departures include 17 Dec 2027 and 30 Jan 2028. A NestCruise advisor can confirm current availability.