Cruise itinerary
16-Night Americas Cruise from San Diego, California
16 nights · Americas · 9 ports of call
16-night Americas cruise aboard Nieuw Amsterdam, departing San Diego, California and calling at Puerto Vallarta, Huatulco (Santa María Huatulco), Puerto Chiapas, Puerto Quetzal, Acajutla and Cartagena and 2 more.
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- 10,000+ sailings
At a glance
- Ship
- Nieuw Amsterdam
- Cruise line
- Holland America Line
- Duration
- 16 nights
- Region
- Americas · South America · Panama Canal
- Departs
- San Diego, California
- Returns
- Fort Lauderdale, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Nieuw Amsterdam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
San Diego, California
Depart 16:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day2At sea
- Day3At sea
- Day4
Puerto Vallarta
Arrive 08:00 · Depart 17:00
A resort city on Mexico's Pacific coast, set where the Sierra Madre meets Banderas Bay. Its cobbled Zona Romántica and the seaside Malecón promenade anchor an old town of churches and galleries, with whale-watching in the bay through the winter months.
- The Malecón
- Zona Romántica
- Banderas Bay
- Day5At sea
- Day6
Huatulco (Santa María Huatulco)
Arrive 10:00 · Depart 17:00
- Day7
Puerto Chiapas
Arrive 08:00 · Depart 17:00
- Day8
Puerto Quetzal
Arrive 06:00 · Depart 20:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day9
Acajutla
Arrive 07:00 · Depart 17:00
- Day10At sea
- Day11At sea
- Day12At sea
- Day13
Cartagena
Arrive 12:00 · Depart 18:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day14At sea
- Day15At sea
- Day16
Half Moon Cay
Arrive 08:00 · Depart 14:00
A private island in the Bahamas used by cruise lines as a beach day, set on a crescent of pale sand and shallow turquoise water. The day centres on swimming, watersports, a horseshoe lagoon and a barbecue lunch ashore.
- Crescent beach
- Stingray lagoon
- Watersports
- Day17
Fort Lauderdale, Florida
Arrive 07:00
A South Florida port often called the yachting capital, fringed by canals and the long sands of Fort Lauderdale Beach. Port Everglades is among the world's busiest cruise gateways, with Las Olas Boulevard's shops and cafés minutes from the piers.
- Port Everglades
- Las Olas Boulevard
- Fort Lauderdale Beach
Upcoming departures
- 2 Oct 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
16-Night Americas Cruise from San Diego, California FAQ
Which ports does this cruise visit?
This 16-night Americas cruise calls at San Diego, California, Puerto Vallarta, Huatulco (Santa María Huatulco), Puerto Chiapas, Puerto Quetzal, Acajutla, Cartagena, Half Moon Cay and Fort Lauderdale, Florida.
How many days are spent at sea?
8 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from San Diego, California and ends in Fort Lauderdale, Florida.
How long is this cruise?
16 nights aboard Nieuw Amsterdam.
When does this itinerary sail?
Upcoming departures include 2 Oct 2026. A NestCruise advisor can confirm current availability.