Cruise itinerary
11-Night Mediterranean Cruise from Piraeus-Athens
11 nights · Mediterranean · 8 ports of call
11-night Mediterranean cruise aboard Enchanted Princess, departing Piraeus-Athens and calling at Santorini Island, Kusadasi, Istanbul, Rhodes Island, Messina and Valletta and 1 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Princess Cruises
- Duration
- 11 nights
- Region
- Mediterranean
- Departs
- Piraeus-Athens
- Returns
- Civitavecchia-Rome
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Enchanted Princess sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Piraeus-Athens
Depart 19:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day2
Santorini Island
Arrive 07:00 · Depart 19:00
The crescent rim of a flooded volcanic caldera in the Greek Cyclades, its whitewashed villages strung along cliffs high above the sea. Fira and Oia draw crowds for sunset views, while the caldera's dark beaches and the ancient site of Akrotiri lie below.
- Oia sunset
- Fira town
- Caldera cliffs
- Day3
Kusadasi
Arrive 07:00 · Depart 16:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day4
Istanbul
Arrive 13:00 · Depart 23:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day5At sea
- Day6At sea
- Day7
Rhodes Island
Arrive 07:00 · Depart 17:00
The largest of Greece's Dodecanese islands, off the Turkish coast, with one of Europe's best-preserved medieval walled towns. The Old Town keeps the cobbled Street of the Knights and the Palace of the Grand Master, while Lindos and its acropolis lie down the coast.
- Medieval Old Town
- Palace of the Grand Master
- Lindos Acropolis
- Day8At sea
- Day9
Messina
Arrive 08:00 · Depart 18:00
A Sicilian port on the strait that separates the island from mainland Italy, framed by the Peloritani mountains. Its harbour clock tower performs an elaborate noon display, and the town is a common gateway to Taormina and the slopes of Mount Etna.
- Etna day trips
- Taormina gateway
- Astronomical clock
- Day10
Valletta
Arrive 08:00 · Depart 21:00
Malta's fortified harbour capital, built by the Knights of St. John on a peninsula between two deep ports. Honey-coloured limestone defines St. John's Co-Cathedral, the Grand Master's Palace and the bastions overlooking the Grand Harbour.
- Grand Harbour
- St. John's Co-Cathedral
- Upper Barrakka Gardens
- Day11At sea
- Day12
Civitavecchia-Rome
Arrive 06:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
Upcoming departures
- 25 Sep 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
11-Night Mediterranean Cruise from Piraeus-Athens FAQ
Which ports does this cruise visit?
This 11-night Mediterranean cruise calls at Piraeus-Athens, Santorini Island, Kusadasi, Istanbul, Rhodes Island, Messina, Valletta and Civitavecchia-Rome.
How many days are spent at sea?
4 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Piraeus-Athens and ends in Civitavecchia-Rome.
How long is this cruise?
11 nights aboard Enchanted Princess.
When does this itinerary sail?
Upcoming departures include 25 Sep 2026. A NestCruise advisor can confirm current availability.