Cruise itinerary
11-Night Mediterranean Cruise from Istanbul
11 nights · Mediterranean · 10 ports of call
11-night Mediterranean cruise aboard Enchanted Princess, departing Istanbul and calling at Kusadasi, Rhodes Island, Mykonos Island, Souda-Chania, Valletta and Palermo and 3 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Princess Cruises
- Duration
- 11 nights
- Region
- Mediterranean
- Departs
- Istanbul
- Returns
- Civitavecchia-Rome
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Enchanted Princess sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Istanbul
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day2
Istanbul
Arrive 12:00 · Depart 12:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day3
Kusadasi
Arrive 09:00 · Depart 19:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day4
Rhodes Island
Arrive 08:00 · Depart 18:00
The largest of Greece's Dodecanese islands, off the Turkish coast, with one of Europe's best-preserved medieval walled towns. The Old Town keeps the cobbled Street of the Knights and the Palace of the Grand Master, while Lindos and its acropolis lie down the coast.
- Medieval Old Town
- Palace of the Grand Master
- Lindos Acropolis
- Day5
Mykonos Island
Arrive 07:00 · Depart 21:00
A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
- Windmills
- Little Venice
- Chora town
- Day6
Souda-Chania
Arrive 08:00 · Depart 18:00
The port of Chania on the northwest coast of Crete, set beside Souda Bay, one of the Mediterranean's deepest natural harbours. It opens onto the old Venetian quarter of Chania, with its lighthouse, harbour-front, and lanes of the former Turkish town.
- Chania old town
- Venetian lighthouse
- Souda Bay
- Day7At sea
- Day8
Valletta
Arrive 07:00 · Depart 17:00
Malta's fortified harbour capital, built by the Knights of St. John on a peninsula between two deep ports. Honey-coloured limestone defines St. John's Co-Cathedral, the Grand Master's Palace and the bastions overlooking the Grand Harbour.
- Grand Harbour
- St. John's Co-Cathedral
- Upper Barrakka Gardens
- Day9
Palermo
Arrive 10:00 · Depart 20:00
The capital of Sicily, a port city layered with Arab, Norman, and Baroque history on the island's north coast. Palermo is known for its mosaic-rich Cappella Palatina, lively street-food markets, and the Norman cathedral at nearby Monreale.
- Cappella Palatina
- Ballarò market
- Monreale mosaics
- Day10
Messina
Arrive 07:00 · Depart 17:00
A Sicilian port on the strait that separates the island from mainland Italy, framed by the Peloritani mountains. Its harbour clock tower performs an elaborate noon display, and the town is a common gateway to Taormina and the slopes of Mount Etna.
- Etna day trips
- Taormina gateway
- Astronomical clock
- Day11
Naples
Arrive 07:00 · Depart 18:00
A southern Italian port on its namesake bay, in the shadow of Mount Vesuvius. Ships dock near the historic centre, the gateway to Pompeii, the cliffs of the Amalfi Coast and the island of Capri, in a city that claims to have invented pizza.
- Mount Vesuvius
- Pompeii
- Gateway to Capri
- Day12
Civitavecchia-Rome
Arrive 06:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
Upcoming departures
- 1 Jun 2027
- 14 Sep 2027
- 26 Oct 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
11-Night Mediterranean Cruise from Istanbul FAQ
Which ports does this cruise visit?
This 11-night Mediterranean cruise calls at Istanbul, Kusadasi, Rhodes Island, Mykonos Island, Souda-Chania, Valletta, Palermo, Messina, Naples and Civitavecchia-Rome.
How many days are spent at sea?
1 day is spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Istanbul and ends in Civitavecchia-Rome.
How long is this cruise?
11 nights aboard Enchanted Princess.
When does this itinerary sail?
Upcoming departures include 1 Jun 2027, 14 Sep 2027 and 26 Oct 2027. A NestCruise advisor can confirm current availability.