Cruise itinerary
18-Night Caribbean Cruise from San Diego, California
18 nights · Caribbean · 9 ports of call
18-night Caribbean cruise aboard Crystal Serenity, departing San Diego, California and calling at At Sea, Topolobampo, La Paz, Isla Natividad, Manzanillo, Mexico and Puerto Vallarta and 2 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Crystal Serenity
- Cruise line
- Crystal
- Duration
- 18 nights
- Region
- Caribbean · Americas · South America
- Departs
- San Diego, California
- Returns
- San Diego, California
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Crystal Serenity sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
San Diego, California
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day2
At Sea
- Day3
At Sea
- Day4
Topolobampo
- Day5
At Sea
- Day6At sea
- Day7
La Paz
- Day8
At Sea
- Day9
Isla Natividad
- Day10
San Diego, California
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day11
At Sea
- Day12
At Sea
- Day13
Manzanillo, Mexico
- Day14
Puerto Vallarta
A resort city on Mexico's Pacific coast, set where the Sierra Madre meets Banderas Bay. Its cobbled Zona Romántica and the seaside Malecón promenade anchor an old town of churches and galleries, with whale-watching in the bay through the winter months.
- The Malecón
- Zona Romántica
- Banderas Bay
- Day15
Mazatlán
A Pacific-coast resort city in Sinaloa, Mexico, strung along one of the longest seafront promenades in the country. The old town centres on the cathedral and Plaza Machado, while the Golden Zone draws beachgoers and the working harbour still lands shrimp.
- El Malecón
- Old Mazatlán
- Stone Island
- Day16
Cabo San Lucas
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day17
Cabo San Lucas
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day18
At Sea
- Day19
San Diego, California
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
Upcoming departures
- 21 Dec 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
18-Night Caribbean Cruise from San Diego, California FAQ
Which ports does this cruise visit?
This 18-night Caribbean cruise calls at San Diego, California, At Sea, Topolobampo, La Paz, Isla Natividad, Manzanillo, Mexico, Puerto Vallarta, Mazatlán and Cabo San Lucas.
How many days are spent at sea?
8 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from San Diego, California.
How long is this cruise?
18 nights aboard Crystal Serenity.
When does this itinerary sail?
Upcoming departures include 21 Dec 2026. A NestCruise advisor can confirm current availability.