Cruise itinerary
15-Night Caribbean Cruise from San Diego, California
15 nights · Caribbean · 12 ports of call
15-night Caribbean cruise aboard Crystal Serenity, departing San Diego, California and calling at At Sea, Cabo San Lucas, Mazatlán, Puerto Vallarta, Acajutla and Playa Flamingo and 5 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Crystal Serenity
- Cruise line
- Crystal
- Duration
- 15 nights
- Region
- Caribbean · Americas · South America
- Departs
- San Diego, California
- Returns
- Callao
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Crystal Serenity sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
San Diego, California
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day2
At Sea
- Day3
Cabo San Lucas
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day4
Mazatlán
A Pacific-coast resort city in Sinaloa, Mexico, strung along one of the longest seafront promenades in the country. The old town centres on the cathedral and Plaza Machado, while the Golden Zone draws beachgoers and the working harbour still lands shrimp.
- El Malecón
- Old Mazatlán
- Stone Island
- Day5
Puerto Vallarta
A resort city on Mexico's Pacific coast, set where the Sierra Madre meets Banderas Bay. Its cobbled Zona Romántica and the seaside Malecón promenade anchor an old town of churches and galleries, with whale-watching in the bay through the winter months.
- The Malecón
- Zona Romántica
- Banderas Bay
- Day6
At Sea
- Day7
At Sea
- Day8
Acajutla
- Day9
Playa Flamingo
- Day10
Puntarenas
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day11
At Sea
- Day12
Manta
- Day13
Guayaquil
- Day14
At Sea
- Day15
Salaverry
- Day16
Callao
Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.
- Gateway to Lima
- Miraflores
- Historic centre
Upcoming departures
- 8 Jan 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
15-Night Caribbean Cruise from San Diego, California FAQ
Which ports does this cruise visit?
This 15-night Caribbean cruise calls at San Diego, California, At Sea, Cabo San Lucas, Mazatlán, Puerto Vallarta, Acajutla, Playa Flamingo, Puntarenas, Manta, Guayaquil, Salaverry and Callao.
How many days are spent at sea?
5 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from San Diego, California and ends in Callao.
How long is this cruise?
15 nights aboard Crystal Serenity.
When does this itinerary sail?
Upcoming departures include 8 Jan 2027. A NestCruise advisor can confirm current availability.