

Cruise itinerary
49-Night South America Cruise from Valparaiso
49 nights · South America · 25 ports of call
49-night South America cruise aboard Azamara Quest, departing Valparaiso and calling at Puerto Montt, Chiloe Island Chile, Puerto Chacabuco, Punta Arenas, Ushuaia and Antarctic Peninsula and 18 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Azamara Quest
- Cruise line
- Azamara
- Duration
- 49 nights
- Region
- South America
- Departs
- Valparaiso
- Returns
- Bridgetown
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Azamara Quest sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1

Valparaiso
Depart 18:00
A historic port city on Chile's central coast, built across steep hills laced with funiculars and painted houses. A UNESCO World Heritage site, it serves as the gateway to Santiago and the Casablanca wine valley, with a busy working harbour below.
- Hillside funiculars
- Cerro Concepción
- Casablanca wineries
- Day2At sea
- Day3

Puerto Montt
Arrive 11:30 · Depart 20:00
A port city in Chile's Lake District, set on the Reloncaví Sound where the central valley meets the fjords of Patagonia. Snow-capped volcanoes ring the bay, and the town is a launch point for trips to lakes, the German-influenced settlement of Puerto Varas and Chiloé island.
- Osorno Volcano
- Puerto Varas
- Angelmó market
- Day4
Chiloe Island Chile
Arrive 08:00 · Depart 16:00
- Day5

Puerto Chacabuco
Arrive 08:00 · Depart 18:00
- Day6At sea
- Day7At sea
- Day8At sea
- Day9

Punta Arenas
Arrive 08:00 · Depart 07:00
A windswept city on the Strait of Magellan in Chilean Patagonia, one of the southernmost ports on earth. It serves as a gateway to Tierra del Fuego, Antarctic crossings and nearby penguin colonies, with a grand central plaza recalling the wool and shipping boom.
- Strait of Magellan
- Plaza de Armas
- Penguin colonies
- Day10At sea
- Day11

Ushuaia
Arrive 06:00 · Depart 06:00
The world's southernmost city, on Argentina's Tierra del Fuego at the tip of South America. Backed by snowy peaks on the Beagle Channel, it is the chief departure port for Antarctica and a base for the Patagonian wilderness.
- Beagle Channel
- Tierra del Fuego park
- End of the world
- Day12At sea
- Day13

Antarctic Peninsula
The northernmost reach of the Antarctic continent, stretching toward South America across the Drake Passage. Expedition ships thread channels of tabular icebergs past glaciers and rocky shores crowded with penguin rookeries, seals and seabirds.
- Penguin rookeries
- Tabular icebergs
- Glacier channels
- Day14At sea
- Day15At sea
- Day16At sea
- Day17

Port Stanley
Arrive 08:00 · Depart 17:00
The small capital of the Falkland Islands in the South Atlantic, a row of brightly painted houses and tin roofs along a sheltered harbour. Penguin colonies and windswept moorland surround the settlement, with Christ Church Cathedral and its whalebone arch at the waterfront.
- Penguin colonies
- Whalebone Arch
- Christ Church Cathedral
- Day18At sea
- Day19At sea
- Day20

Punta del Este
Arrive 09:00 · Depart 18:00
- Day21

Montevideo
Arrive 08:00 · Depart 18:00
The capital of Uruguay, set on the north bank of the broad Río de la Plata. Its old town keeps colonial plazas and a long riverside promenade, the Rambla, in a relaxed South American port city known for grilled meat and mate.
- Ciudad Vieja
- The Rambla
- Plaza Independencia
- Day22At sea
- Day23

Buenos Aires
Arrive 06:00 · Depart 06:00
Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
- La Boca
- San Telmo
- Tango culture
- Day24At sea
- Day25At sea
- Day26

Montevideo
Arrive 08:00 · Depart 17:00
The capital of Uruguay, set on the north bank of the broad Río de la Plata. Its old town keeps colonial plazas and a long riverside promenade, the Rambla, in a relaxed South American port city known for grilled meat and mate.
- Ciudad Vieja
- The Rambla
- Plaza Independencia
- Day27

Rio Grande
Arrive 14:00 · Depart 21:00
- Day28At sea
- Day29

Porto Belo
Arrive 07:00 · Depart 18:00
- Day30

São Francisco do Sul
Arrive 07:00 · Depart 18:00
- Day31

Paranaguá
Arrive 07:00 · Depart 20:00
- Day32

Santos
Arrive 08:30 · Depart 22:00
Brazil's busiest port, on the coast of São Paulo state and the main gateway to that vast city. Its waterfront sits below green coastal hills, with historic coffee-trade buildings, an aquarium and long urban beaches backed by a seafront garden.
- Coffee Museum
- Santos beach gardens
- Pelé Museum
- Day33

Ilhabela
Arrive 07:00 · Depart 20:00
- Day34
Paraty, Rio De Janeiro
Arrive 07:00 · Depart 23:00
- Day35

Rio de Janeiro
Arrive 08:00 · Depart 08:00
Brazil's great coastal city, set between forested mountains and the Atlantic. The Christ the Redeemer statue looks down from Corcovado, Sugarloaf rises over the harbour mouth, and the sands of Copacabana and Ipanema run along the city's southern edge.
- Christ the Redeemer
- Sugarloaf Mountain
- Copacabana Beach
- Day36At sea
- Day37At sea
- Day38At sea
- Day39

Salvador de Bahia
Arrive 13:00 · Depart 17:00
Brazil's first colonial capital, set on a bluff above the Bay of All Saints. The cobbled Pelourinho district holds pastel baroque churches and the rhythms of Afro-Brazilian culture, with capoeira, candomblé and acarajé stalls woven into daily life.
- Pelourinho
- Elevador Lacerda
- Acarajé
- Day40At sea
- Day41At sea
- Day42

Natal
Arrive 10:30 · Depart 20:00
- Day43At sea
- Day44At sea
- Day45

Belem
Arrive 08:00 · Depart 18:00
- Day46At sea
- Day47
Iles du Salut
Arrive 08:00 · Depart 17:00
- Day48At sea
- Day49

Scarborough
Arrive 08:00 · Depart 18:00
- Day50

Bridgetown
Arrive 08:00
The capital of Barbados on the island's southwest coast, a long-standing Caribbean cruise port. Its colonial centre and Garrison Savannah are UNESCO-listed, with the white sand of Carlisle Bay and turtle-filled waters close to the harbour.
- Carlisle Bay
- Garrison Savannah
- Rum distilleries
Upcoming departures
- 24 Jan 2028
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
49-Night South America Cruise from Valparaiso FAQ
Which ports does this cruise visit?
This 49-night South America cruise calls at Valparaiso, Puerto Montt, Chiloe Island Chile, Puerto Chacabuco, Punta Arenas, Ushuaia, Antarctic Peninsula, Port Stanley, Punta del Este, Montevideo, Buenos Aires, Rio Grande, Porto Belo, São Francisco do Sul, Paranaguá, Santos, Ilhabela, Paraty, Rio De Janeiro, Rio de Janeiro, Salvador de Bahia, Natal, Belem, Iles du Salut, Scarborough and Bridgetown.
How many days are spent at sea?
24 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Valparaiso and ends in Bridgetown.
How long is this cruise?
49 nights aboard Azamara Quest.
When does this itinerary sail?
Upcoming departures include 24 Jan 2028. A NestCruise advisor can confirm current availability.