Azamara Quest — 42-Night South America Cruise from Miami, Florida

Cruise itinerary

42-Night South America Cruise from Miami, Florida

42 nights · South America · 23 ports of call

42-night South America cruise aboard Azamara Quest, departing Miami, Florida and calling at Cozumel, Belize City, Roatán Island, Puerto Limón, Bocas del Toro and Panama Canal Transit and 16 more.

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At a glance

Ship: Azamara Quest
Cruise line: Azamara
Duration: 42 nights
Region: South America
Departs: Miami, Florida
Returns: Buenos Aires

How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Azamara Quest sailing, typically within 24 hours.

Where this voyage takes you

Voyage route — calls shown in order; map is schematic.

Day-by-day itinerary

Day
1
- Miami, Florida
  Depart 18:00
  The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
  - South Beach
  - Little Havana
  - Wynwood murals
Day
2
At sea
Day
3
- Cozumel
  Arrive 08:00 · Depart 18:00
  An island off Mexico's Yucatán coast in the Caribbean, a leading port for snorkelling and diving. Ships dock beside its reefs, part of the Mesoamerican system, with beach clubs, Mayan ruins and the resort strip of the Riviera Maya within reach.
  - Coral reefs
  - Mayan ruins
  - Beach clubs
Day
4
- Belize City
  Arrive 08:00 · Depart 15:00
  The largest city in Belize, on the Caribbean coast where the Belize River meets the sea. A tender port for many ships, it opens the way to the world's second-largest barrier reef, jungle Maya ruins and cave-tubing excursions inland.
  - Barrier reef
  - Maya ruins
  - Cave tubing
Day
5
- Roatán Island
  Arrive 08:00 · Depart 18:00
  An island off the northern coast of Honduras in the western Caribbean, part of the Bay Islands. Roatán is known for the Mesoamerican Barrier Reef just offshore, the dive sites and beaches around West End and West Bay, and forested inland hills.
  - West Bay Beach
  - Barrier reef diving
  - West End
Day
6
At sea
Day
7
- Puerto Limón
  Arrive 10:30 · Depart 22:00
  A Caribbean port on Costa Rica's humid eastern coast, the country's main Atlantic harbour. It opens onto rainforest, banana plantations and the canals of Tortuguero, with white-faced monkeys and sloths a frequent sight on excursions inland.
  - Tortuguero canals
  - Rainforest wildlife
  - Banana country
Day
8
- Bocas del Toro
  Arrive 08:00 · Depart 18:00
Day
9
- Panama City
  Arrive 18:00 · Depart 18:00
  Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
  - Panama Canal
  - Casco Viejo
  - Miraflores Locks
Day
10
At sea
Day
11
At sea
Day
12
- Manta
  Arrive 08:00 · Depart 13:30
Day
13
At sea
Day
14
- Callao
  Arrive 13:00 · Depart 17:00
  Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.
  - Gateway to Lima
  - Miraflores
  - Historic centre
Day
15
At sea
Day
16
- Pisco
  Arrive 08:00 · Depart 16:00
Day
17
At sea
Day
18
At sea
Day
19
- Coquimbo
  Arrive 09:30 · Depart 16:30
Day
20
- Valparaiso
  Arrive 07:00 · Depart 07:00
  A historic port city on Chile's central coast, built across steep hills laced with funiculars and painted houses. A UNESCO World Heritage site, it serves as the gateway to Santiago and the Casablanca wine valley, with a busy working harbour below.
  - Hillside funiculars
  - Cerro Concepción
  - Casablanca wineries
Day
21
At sea
Day
22
- Puerto Montt
  Arrive 11:30 · Depart 20:00
  A port city in Chile's Lake District, set on the Reloncaví Sound where the central valley meets the fjords of Patagonia. Snow-capped volcanoes ring the bay, and the town is a launch point for trips to lakes, the German-influenced settlement of Puerto Varas and Chiloé island.
  - Osorno Volcano
  - Puerto Varas
  - Angelmó market
Day
23
- Chiloe Island Chile
  Arrive 08:00 · Depart 16:00
Day
24
- Puerto Chacabuco
  Arrive 08:00 · Depart 18:00
Day
25
At sea
Day
26
At sea
Day
27
At sea
Day
28
- Punta Arenas
  Arrive 08:00 · Depart 07:00
  A windswept city on the Strait of Magellan in Chilean Patagonia, one of the southernmost ports on earth. It serves as a gateway to Tierra del Fuego, Antarctic crossings and nearby penguin colonies, with a grand central plaza recalling the wool and shipping boom.
  - Strait of Magellan
  - Plaza de Armas
  - Penguin colonies
Day
29
At sea
Day
30
- Ushuaia
  Arrive 06:00 · Depart 06:00
  The world's southernmost city, on Argentina's Tierra del Fuego at the tip of South America. Backed by snowy peaks on the Beagle Channel, it is the chief departure port for Antarctica and a base for the Patagonian wilderness.
  - Beagle Channel
  - Tierra del Fuego park
  - End of the world
Day
31
At sea
Day
32
- Antarctic Peninsula
  The northernmost reach of the Antarctic continent, stretching toward South America across the Drake Passage. Expedition ships thread channels of tabular icebergs past glaciers and rocky shores crowded with penguin rookeries, seals and seabirds.
  - Penguin rookeries
  - Tabular icebergs
  - Glacier channels
Day
33
At sea
Day
34
At sea
Day
35
At sea
Day
36
- Port Stanley
  Arrive 08:00 · Depart 17:00
  The small capital of the Falkland Islands in the South Atlantic, a row of brightly painted houses and tin roofs along a sheltered harbour. Penguin colonies and windswept moorland surround the settlement, with Christ Church Cathedral and its whalebone arch at the waterfront.
  - Penguin colonies
  - Whalebone Arch
  - Christ Church Cathedral
Day
37
At sea
Day
38
At sea
Day
39
- Punta del Este
  Arrive 09:00 · Depart 18:00
Day
40
- Montevideo
  Arrive 08:00 · Depart 18:00
  The capital of Uruguay, set on the north bank of the broad Río de la Plata. Its old town keeps colonial plazas and a long riverside promenade, the Rambla, in a relaxed South American port city known for grilled meat and mate.
  - Ciudad Vieja
  - The Rambla
  - Plaza Independencia
Day
41
At sea
Day
42
- Buenos Aires
  Arrive 06:00 · Depart 06:00
  Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
  - La Boca
  - San Telmo
  - Tango culture
Day
43
- Buenos Aires
  Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
  - La Boca
  - San Telmo
  - Tango culture

Upcoming departures

5 Jan 2028

Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.

42-Night South America Cruise from Miami, Florida FAQ

Which ports does this cruise visit?

This 42-night South America cruise calls at Miami, Florida, Cozumel, Belize City, Roatán Island, Puerto Limón, Bocas del Toro, Panama Canal Transit, Panama City, Manta, Callao, Pisco, Coquimbo, Valparaiso, Puerto Montt, Chiloe Island Chile, Puerto Chacabuco, Punta Arenas, Ushuaia, Antarctic Peninsula, Port Stanley, Punta del Este, Montevideo and Buenos Aires.

How many days are spent at sea?

20 days are spent at sea; the rest are in port.

Where does this cruise depart from?

It departs from Miami, Florida and ends in Buenos Aires.

How long is this cruise?

42 nights aboard Azamara Quest.

When does this itinerary sail?

Upcoming departures include 5 Jan 2028. A NestCruise advisor can confirm current availability.

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About: Azamara Quest — 42-Night South America Cruise from Miami, Florida

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