Cruise itinerary
18-Night Americas Cruise from Miami, Florida
18 nights · Americas · 9 ports of call
18-night Americas cruise aboard Azamara Quest, departing Miami, Florida and calling at Cabo Rojo, Cartagena, Panama Canal Transit, Puntarenas, Puerto Quetzal and Puerto Vallarta and 2 more.
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At a glance
- Ship
- Azamara Quest
- Cruise line
- Azamara
- Duration
- 18 nights
- Region
- Americas · South America · Panama Canal
- Departs
- Miami, Florida
- Returns
- San Francisco International Airport
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Azamara Quest sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Miami, Florida
Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day2At sea
- Day3At sea
- Day4
Cabo Rojo
Arrive 8:00 · Depart 18:00
A remote stretch of the Dominican Republic's far southwest, near the Pedernales frontier with Haiti. The wider region is known for the turquoise water of Bahía de las Águilas and the arid Jaragua National Park.
- Bahía de las Águilas
- Jaragua park
- Caribbean coast
- Day5At sea
- Day6
Cartagena
Arrive 7:00 · Depart 13:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day7
Panama Canal Transit
Arrive 5:00 · Depart 17:00
- Day8At sea
- Day9
Puntarenas
Arrive 8:00 · Depart 20:00
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day10At sea
- Day11
Puerto Quetzal
Arrive 8:00 · Depart 16:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day12At sea
- Day13At sea
- Day14
Puerto Vallarta
Arrive 9:00 · Depart 23:00
A resort city on Mexico's Pacific coast, set where the Sierra Madre meets Banderas Bay. Its cobbled Zona Romántica and the seaside Malecón promenade anchor an old town of churches and galleries, with whale-watching in the bay through the winter months.
- The Malecón
- Zona Romántica
- Banderas Bay
- Day15At sea
- Day16At sea
- Day17
San Diego, California
Arrive 15:00 · Depart 22:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day18At sea
- Day19
San Francisco International Airport
Arrive 6:00
Upcoming departures
- 18 Dec 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
18-Night Americas Cruise from Miami, Florida FAQ
Which ports does this cruise visit?
This 18-night Americas cruise calls at Miami, Florida, Cabo Rojo, Cartagena, Panama Canal Transit, Puntarenas, Puerto Quetzal, Puerto Vallarta, San Diego, California and San Francisco International Airport.
How many days are spent at sea?
10 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Miami, Florida and ends in San Francisco International Airport.
How long is this cruise?
18 nights aboard Azamara Quest.
When does this itinerary sail?
Upcoming departures include 18 Dec 2026. A NestCruise advisor can confirm current availability.