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Cruises from La Romana

12 live cruises sail from La Romana — 4 to 7 nights, across one line, through the Caribbean. A NestCruise advisor narrows them to the one that fits.

12 sailings
MSC OperaCaribbean

MSC Cruises

La Romana, Catalina Island, Oranjestad, Willemstad, Kralendijk, Saint George, La Romana

Aboard MSC Opera

La Romana → Catalina Island → Oranjestad → Willemstad +2 more

7 nights · 6 departures

Port-rich · 6 ports

Mar 2027 – Jan 2028View details →
MSC OperaCaribbean

MSC Cruises

La Romana, Catalina Island, Virgin Gorda, Philipsburg, Basseterre, St John s, La Romana

Aboard MSC Opera

La Romana → Catalina Island → Virgin Gorda → Philipsburg +2 more

7 nights · 6 departures

Port-rich · 6 ports

Mar 2027 – Jan 2028View details →
MSC OperaCaribbean

MSC Cruises

La Romana, Catalina Island, Virgin Gorda, Philipsburg, Fort de France, St John s, La Romana

Aboard MSC Opera

La Romana → Catalina Island → Virgin Gorda → Philipsburg +2 more

7 nights · 6 departures

Port-rich · 6 ports

Apr 2027 – Jun 2027View details →
MSC OperaCaribbean

MSC Cruises

La Romana, La Romana

Aboard MSC Opera

La Romana → Catalina Island → Oranjestad → Willemstad +6 more

14 nights · 6 departures

Balanced · 10 ports

Apr 2027 – May 2027View details →
MSC OperaCaribbean

MSC Cruises

La Romana, Virgin Gorda, Philipsburg, Basseterre, Road Town, Catalina Island, La Romana

Aboard MSC Opera

La Romana → Virgin Gorda → Philipsburg → Basseterre, Saint Kitts +2 more

7 nights · 5 departures

Port-rich · 6 ports

Dec 2026 – Mar 2027View details →
MSC OperaCaribbean

MSC Cruises

La Romana, Catalina Island, Bridgetown, Fort de France, St John s, Road Town, La Romana

Aboard MSC Opera

La Romana → Catalina Island → Bridgetown → Fort-de-France +2 more

7 nights · 4 departures

Port-rich · 6 ports

Dec 2026 – Mar 2027View details →
MSC OperaCaribbean

MSC Cruises

Dominican Republic, Barbados, Martinique, Guadeloupe, Virgin Islands (British)

Aboard MSC Opera

La Romana → Catalina Island → Bridgetown → Fort-de-France +2 more

7 nights · 4 departures

Port-rich · 6 ports

Nov 2026 – Feb 2027View details →
MSC OperaCaribbean

MSC Cruises

La Romana, Samana Bay, Virgin Gorda, Basseterre, Philipsburg, Catalina Island, La Romana

Aboard MSC Opera

La Romana → Samaná → Virgin Gorda → Basseterre, Saint Kitts +2 more

7 nights · 3 departures

Port-rich · 6 ports

Dec 2026 – Jan 2027View details →
MSC OperaCaribbean

MSC Cruises

Dominican Republic, Barbados

Aboard MSC Opera

La Romana → Catalina Island → Bridgetown

3 nights · 1 departure

Balanced · 3 ports

Nov 2026View details →
MSC OperaCaribbean

MSC Cruises

La Romana, Catalina Island, Bridgetown, Fort de France

Aboard MSC Opera

La Romana → Catalina Island → Bridgetown → Fort-de-France

4 nights · 1 departure

Port-rich · 4 ports

Apr 2027View details →
MSC OperaCaribbean

MSC Cruises

La Romana, Catalina Island, Bridgetown, Fort de France, St John s, Virgin Gorda, La Romana

Aboard MSC Opera

La Romana → Catalina Island → Bridgetown → Fort-de-France +2 more

7 nights · 1 departure

Port-rich · 6 ports

Jan 2027View details →
MSC OperaCaribbean

MSC Cruises

La Romana, Samana Bay, Virgin Gorda, Philipsburg, Basseterre, Catalina Island, La Romana

Aboard MSC Opera

La Romana → Samaná → Virgin Gorda → Philipsburg +2 more

7 nights · 1 departure

Port-rich · 6 ports

Nov 2026View details →

Frequently asked

How many cruises from La Romana does NestCruise have?
12 live sailings, 4 to 7 nights. A NestCruise advisor narrows them to the one that fits.
Which cruise lines sail from La Romana?
MSC Cruises, among others.
How long are cruises from La Romana?
Most run 4 to 7 nights.
How much do cruises from La Romana cost?
NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.