Cruises from Colón
15 live cruises sail from Colón — 7 to 10 nights, across 2 lines, through the Caribbean. A NestCruise advisor narrows them to the one that fits.
CaribbeanRoyal Caribbean International
7 Night Southern Caribbean Cruise
Aboard Grandeur of the Seas
Colón → Cartagena → Oranjestad → Willemstad
7 nights · 2 departures
Sea-paced · 4 ports
AmericasPONANT EXPLORATIONS
Secrets of Central America
Aboard Le Bellot
Colón → Fuerte San Lorenzo → San Blas Islands → Panama Canal Transit +8 more
10 nights · 6 departures
Port-rich · 12 ports
AmericasPONANT EXPLORATIONS
Central America Jewels & Panama Canal
Aboard Le Lapérouse
Colón → San Blas Islands → Portobelo → Panama Canal Transit +4 more
7 nights · 3 departures
Port-rich · 8 ports
AmericasPONANT EXPLORATIONS
Secrets of Central America
Aboard Le Bougainville
Colón → Fuerte San Lorenzo → San Blas Islands → Panama Canal Transit +8 more
10 nights · 3 departures
Port-rich · 12 ports
AmericasPONANT EXPLORATIONS
From Panama’s wild beauty to Peruvian shores
Aboard L'Austral
Colón → San Blas Islands → Panama Canal Transit → Fuerte Amador +4 more
10 nights · 1 departure
Port-rich · 8 ports
CaribbeanRoyal Caribbean International
7 Nt Southern Caribbean Holiday Cruise
Aboard Grandeur of the Seas
Colón → Cartagena → Oranjestad → Kralendijk
7 nights · 2 departures
Sea-paced · 4 ports
AmericasPONANT EXPLORATIONS
Central America Jewels & Panama Canal
Aboard Le Bellot
Colón → San Blas Islands → Panama Canal Transit → Fuerte Amador +4 more
7 nights · 2 departures
Port-rich · 8 ports
AmericasPONANT EXPLORATIONS
Secrets of Central America
Aboard Le Lapérouse
Colón → Fuerte San Lorenzo → San Blas Islands → Panama Canal Transit +8 more
10 nights · 2 departures
Port-rich · 12 ports
AmericasPONANT EXPLORATIONS
Central America Jewels & Panama Canal
Aboard Le Bougainville
Colón → San Blas Islands → Panama Canal Transit → Fuerte Amador +4 more
7 nights · 2 departures
Port-rich · 8 ports
RepositioningRoyal Caribbean International
7 Night Colon To San Juan Cruise
Aboard Grandeur of the Seas
Colón → Kingstown → Castries → Saint John's +2 more
7 nights · 1 departure
Port-rich · 6 ports
CaribbeanPONANT EXPLORATIONS
Panama, Colombia & Caribbean Islands
Aboard Le Bellot
Colón → San Blas Islands → Cartagena → Santa Marta +7 more
10 nights · 1 departure
Port-rich · 11 ports
CaribbeanPONANT EXPLORATIONS
Panama, Colombia & Caribbean Islands
Aboard Le Lapérouse
Colón → San Blas Islands → Cartagena → Santa Marta +7 more
10 nights · 1 departure
Port-rich · 11 ports
AmericasPONANT EXPLORATIONS
Panama and Costa Rica by Sea: The Natural Wonders of Central America – with Smithsonian Journeys
Aboard Le Bougainville
Colón → Portobelo → San Blas Islands → Panama Canal Transit +4 more
7 nights · 1 departure
Port-rich · 8 ports
Frequently asked
- How many cruises from Colón does NestCruise have?
- 15 live sailings, 7 to 10 nights. A NestCruise advisor narrows them to the one that fits.
- Which cruise lines sail from Colón?
- PONANT EXPLORATIONS and Royal Caribbean International, among others.
- How long are cruises from Colón?
- Most run 7 to 10 nights.
- How much do cruises from Colón cost?
- NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.