

Cruise itinerary
21-Night Mediterranean Cruise from Barcelona
21 nights · Mediterranean · 14 ports of call
21-night Mediterranean cruise aboard Sun Princess, departing Barcelona and calling at Gibraltar, Cartagena Spain, La Spezia, Civitavecchia-Rome, Naples and Souda-Chania and 7 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Sun Princess
- Cruise line
- Princess Cruises
- Duration
- 21 nights
- Region
- Mediterranean
- Departs
- Barcelona
- Returns
- Barcelona
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Sun Princess sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1

Barcelona
Depart 17:00
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
- Day2At sea
- Day3

Gibraltar
Arrive 07:00 · Depart 16:00
A British territory at the southern tip of Spain, dominated by its towering limestone Rock. Cable cars climb to the summit, home to Europe's only wild monkeys, with sweeping views across the strait toward the coast of Africa.
- The Rock
- Barbary macaques
- St. Michael's Cave
- Day4

Cartagena Spain
Arrive 09:00 · Depart 18:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day5At sea
- Day6At sea
- Day7

La Spezia
Arrive 07:00 · Depart 19:00
A port at the head of a gulf on Italy's Ligurian coast, the gateway to the Cinque Terre and Tuscany. La Spezia is known for its naval harbour and waterfront gardens, with the five cliffside fishing villages and the marble city of Carrara nearby.
- Cinque Terre
- Portovenere
- Carrara marble
- Day8

Civitavecchia-Rome
Arrive 06:00 · Depart 18:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day9

Naples
Arrive 07:00 · Depart 19:00
A southern Italian port on its namesake bay, in the shadow of Mount Vesuvius. Ships dock near the historic centre, the gateway to Pompeii, the cliffs of the Amalfi Coast and the island of Capri, in a city that claims to have invented pizza.
- Mount Vesuvius
- Pompeii
- Gateway to Capri
- Day10At sea
- Day11

Souda-Chania
Arrive 08:00 · Depart 18:00
The port of Chania on the northwest coast of Crete, set beside Souda Bay, one of the Mediterranean's deepest natural harbours. It opens onto the old Venetian quarter of Chania, with its lighthouse, harbour-front, and lanes of the former Turkish town.
- Chania old town
- Venetian lighthouse
- Souda Bay
- Day12At sea
- Day13

Kusadasi
Arrive 07:00 · Depart 18:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day14

Mykonos Island
Arrive 07:00 · Depart 21:00
A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
- Windmills
- Little Venice
- Chora town
- Day15

Piraeus-Athens
Arrive 06:00 · Depart 19:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day16

Santorini Island
Arrive 07:00 · Depart 19:00
The crescent rim of a flooded volcanic caldera in the Greek Cyclades, its whitewashed villages strung along cliffs high above the sea. Fira and Oia draw crowds for sunset views, while the caldera's dark beaches and the ancient site of Akrotiri lie below.
- Oia sunset
- Fira town
- Caldera cliffs
- Day17At sea
- Day18

Bar Montenegro
Arrive 07:30 · Depart 18:00
- Day19

Corfu Island
Arrive 07:00 · Depart 16:00
An Ionian island off Greece's northwest coast, greener and more Venetian-feeling than the Aegean isles. Ships call at its old town, a UNESCO-listed warren of Italianate streets between two hilltop fortresses, with pebbly coves around the shore.
- Old Fortress
- Liston arcade
- Ionian coves
- Day20

Messina
Arrive 07:00 · Depart 16:00
A Sicilian port on the strait that separates the island from mainland Italy, framed by the Peloritani mountains. Its harbour clock tower performs an elaborate noon display, and the town is a common gateway to Taormina and the slopes of Mount Etna.
- Etna day trips
- Taormina gateway
- Astronomical clock
- Day21At sea
- Day22

Barcelona
Arrive 06:00
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
Upcoming departures
- 8 Aug 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
21-Night Mediterranean Cruise from Barcelona FAQ
Which ports does this cruise visit?
This 21-night Mediterranean cruise calls at Barcelona, Gibraltar, Cartagena Spain, La Spezia, Civitavecchia-Rome, Naples, Souda-Chania, Kusadasi, Mykonos Island, Piraeus-Athens, Santorini Island, Bar Montenegro, Corfu Island and Messina.
How many days are spent at sea?
7 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from Barcelona.
How long is this cruise?
21 nights aboard Sun Princess.
When does this itinerary sail?
Upcoming departures include 8 Aug 2026. A NestCruise advisor can confirm current availability.