Cruise itinerary
4-Night Americas Cruise from San Diego, California
4 nights · Americas · 3 ports of call
4-night Americas cruise aboard Serenade of the Seas, departing San Diego, California and calling at Santa Catalina Island, California and Ensenada.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Royal Caribbean International
- Duration
- 4 nights
- Region
- Americas · Central America
- Departs
- San Diego, California
- Returns
- San Diego, California
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Serenade of the Seas sailing, typically within 24 hours.
Where this voyage takes you
- Family Friendly
Day-by-day itinerary
- Day1
San Diego, California
Depart 16:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day2
Santa Catalina Island, California
Arrive 08:00 · Depart 17:00
- Day3
Ensenada
Arrive 08:00 · Depart 16:00
A port city on the Pacific coast of Mexico's Baja California, the peninsula's first stop south of the US border. Its waterfront leads to a famed cantina and a market street, with the La Bufadora marine blowhole on the headland nearby.
- La Bufadora
- Hussong's Cantina
- Coastal wineries
- Day4At sea
- Day5
San Diego, California
Arrive 07:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
Upcoming departures
- 11 Oct 2026
- 29 Nov 2026
- 6 Dec 2026
- 10 Jan 2027
- 17 Jan 2027
- 24 Jan 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
4-Night Americas Cruise from San Diego, California FAQ
Which ports does this cruise visit?
This 4-night Americas cruise calls at San Diego, California, Santa Catalina Island, California and Ensenada.
How many days are spent at sea?
1 day is spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from San Diego, California.
How long is this cruise?
4 nights aboard Serenade of the Seas.
When does this itinerary sail?
Upcoming departures include 11 Oct 2026, 29 Nov 2026, 6 Dec 2026 and 10 Jan 2027. A NestCruise advisor can confirm current availability.