Cruise itinerary
15-Night Americas Cruise from San Diego, California
15 nights · Americas · 8 ports of call
15-night Americas cruise aboard Serenade of the Seas, departing San Diego, California and calling at Puerto Vallarta, Puerto Quetzal, Puntarenas, Panama Canal Transit, Cartagena and Georgetown, Grand Cayman and 1 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Royal Caribbean International
- Duration
- 15 nights
- Region
- Americas · South America · Panama Canal
- Departs
- San Diego, California
- Returns
- Tampa, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Serenade of the Seas sailing, typically within 24 hours.
Where this voyage takes you
- Family Friendly
Day-by-day itinerary
- Day1
San Diego, California
Depart 17:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day2At sea
- Day3At sea
- Day4
Puerto Vallarta
Arrive 08:00 · Depart 17:00
A resort city on Mexico's Pacific coast, set where the Sierra Madre meets Banderas Bay. Its cobbled Zona Romántica and the seaside Malecón promenade anchor an old town of churches and galleries, with whale-watching in the bay through the winter months.
- The Malecón
- Zona Romántica
- Banderas Bay
- Day5At sea
- Day6At sea
- Day7
Puerto Quetzal
Arrive 08:00 · Depart 17:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day8At sea
- Day9
Puntarenas
Arrive 08:00 · Depart 17:00
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day10At sea
- Day11
Panama Canal Transit
Arrive 06:00 · Depart 18:00
- Day12
Cartagena
Arrive 11:30 · Depart 19:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day13At sea
- Day14
Georgetown, Grand Cayman
Arrive 07:00 · Depart 16:00
Grand Cayman's capital and the main port of the Cayman Islands, set on the calm western shore. Cruise ships tender into the harbour beside Seven Mile Beach, with Stingray City sandbars and Caribbean reef diving a short boat ride away.
- Seven Mile Beach
- Stingray City
- Seven Mile reefs
- Day15At sea
- Day16
Tampa, Florida
Arrive 05:00
A port city on Florida's Gulf coast, set on a deep bay and a major embarkation point for Caribbean cruises. Tampa is known for the historic Cuban quarter of Ybor City, the Riverwalk, and the Spanish-Moorish towers of the old Tampa Bay Hotel.
- Ybor City
- Tampa Riverwalk
- Busch Gardens
Upcoming departures
- 7 Oct 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
15-Night Americas Cruise from San Diego, California FAQ
Which ports does this cruise visit?
This 15-night Americas cruise calls at San Diego, California, Puerto Vallarta, Puerto Quetzal, Puntarenas, Panama Canal Transit, Cartagena, Georgetown, Grand Cayman and Tampa, Florida.
How many days are spent at sea?
8 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from San Diego, California and ends in Tampa, Florida.
How long is this cruise?
15 nights aboard Serenade of the Seas.
When does this itinerary sail?
Upcoming departures include 7 Oct 2027. A NestCruise advisor can confirm current availability.