Cruise itinerary
21-Night Europe Cruise from Piraeus
21 nights · Europe · 17 ports of call
21-night Europe cruise aboard Seabourn Quest, departing Piraeus and calling at Gythio, Khania, Mykonos, Çesme, Kusadasi and Istanbul and 10 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Seabourn Quest
- Cruise line
- Seabourn
- Duration
- 21 nights
- Region
- Europe · Southern Europe · Mediterranean · Greek Islands · Aegean · Adriatic
- Departs
- Piraeus
- Returns
- Venice
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seabourn Quest sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Piraeus
Depart 17:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day2
Gythio
Arrive 08:00 · Depart 17:00
A coastal town in the southern Peloponnese of Greece, set on the Laconian Gulf below the Taygetos mountains. A causeway leads to the islet of Cranae, and the abandoned Byzantine hill city of Mystras lies inland near ancient Sparta.
- Cranae islet
- Mystras
- Mani peninsula
- Day3
Khania
Arrive 08:00 · Depart 17:00
A harbour town on the northwest coast of Crete, in Greece, wrapped around a Venetian port. A waterfront lighthouse marks the old harbour mouth, and the pink-sand lagoon of Balos and the beach at Elafonisi lie along the coast to the west.
- Venetian harbour
- Balos lagoon
- Elafonisi beach
- Day4
Mykonos
Arrive 08:00 · Depart 18:00
A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
- Windmills
- Little Venice
- Chora town
- Day5
Çesme
Arrive 08:00 · Depart 18:00
- Day6
Kusadasi
Arrive 08:00 · Depart 23:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day7At sea
- Day8
Istanbul
Arrive 07:00 · Depart 17:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day9
Çanakkale
Arrive 08:00 · Depart 18:00
A Turkish port at the narrowest point of the Dardanelles strait, between the Aegean and the Sea of Marmara. It is the gateway to the ruins of ancient Troy and to the Gallipoli battlefields and war memorials across the water on the peninsula.
- Ancient Troy
- Gallipoli battlefields
- Dardanelles strait
- Day10
Izmir
Arrive 08:00 · Depart 18:00
- Day11
Pátmos
Arrive 08:00 · Depart 17:00
A small Greek island in the Dodecanese, long held sacred in Christian tradition. The hilltop Monastery of Saint John crowns the whitewashed Chóra, near the cave where the Book of Revelation is said to have been written above the harbour at Skala.
- Monastery of St. John
- Cave of the Apocalypse
- Chóra hilltop
- Day12
Rhodes
Arrive 08:00 · Depart 23:00
The largest of Greece's Dodecanese islands, off the Turkish coast, with one of Europe's best-preserved medieval walled towns. The Old Town keeps the cobbled Street of the Knights and the Palace of the Grand Master, while Lindos and its acropolis lie down the coast.
- Medieval Old Town
- Palace of the Grand Master
- Lindos Acropolis
- Day13At sea
- Day14
Spetses
Arrive 08:00 · Depart 17:00
- Day15
Piraeus
Arrive 07:00 · Depart 17:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day16
Gythio
Arrive 08:00 · Depart 17:00
A coastal town in the southern Peloponnese of Greece, set on the Laconian Gulf below the Taygetos mountains. A causeway leads to the islet of Cranae, and the abandoned Byzantine hill city of Mystras lies inland near ancient Sparta.
- Cranae islet
- Mystras
- Mani peninsula
- Day17At sea
- Day18
Dubrovnik
Arrive 08:00 · Depart 22:00
A walled city on Croatia's Dalmatian coast, its limestone old town wrapped in sea-facing ramparts above the Adriatic. Ships call here for the marble main street of Stradun, the circuit of the city walls and the cable car to Mount Srđ.
- City walls
- Stradun
- Mount Srđ cable car
- Day19
Hvar Island
Arrive 08:00 · Depart 18:00
A long, sun-soaked island off the Dalmatian coast of Croatia, known for lavender fields and a marble-paved harbour town. A hilltop Venetian fortress overlooks the bay, and small boats reach the wooded Pakleni islets just offshore.
- Spanish Fortress
- Lavender fields
- Pakleni Islands
- Day20
Zadar
Arrive 08:00 · Depart 18:00
A walled Adriatic city on Croatia's Dalmatian coast, built on a compact peninsula of Roman and Venetian stone. Zadar is known for its waterfront Sea Organ, the solar Greeting to the Sun installation, and Roman ruins at the old forum.
- Sea Organ
- Roman Forum
- Greeting to the Sun
- Day21
Piran
Arrive 08:00 · Depart 18:00
- Day22
Venice
Arrive 07:00
A city built across more than a hundred islands in a lagoon on the Adriatic, threaded by canals instead of streets. Venice is known for St. Mark's Basilica and its piazza, the Grand Canal and Rialto Bridge, and the glass workshops of Murano nearby.
- St. Mark's Square
- Grand Canal
- Rialto Bridge
Upcoming departures
- 21 Jun 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
21-Night Europe Cruise from Piraeus FAQ
Which ports does this cruise visit?
This 21-night Europe cruise calls at Piraeus, Gythio, Khania, Mykonos, Çesme, Kusadasi, Istanbul, Çanakkale, Izmir, Pátmos, Rhodes, Spetses, Dubrovnik, Hvar Island, Zadar, Piran and Venice.
How many days are spent at sea?
3 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Piraeus and ends in Venice.
How long is this cruise?
21 nights aboard Seabourn Quest.
When does this itinerary sail?
Upcoming departures include 21 Jun 2026. A NestCruise advisor can confirm current availability.