

Cruise itinerary
19-Night World Cruise Cruise from Seattle, Washington
19 nights · World Cruise · 9 ports of call
19-night World Cruise cruise aboard MSC Poesia, departing Seattle, Washington and calling at Los Angeles, California, San Diego, California, Cabo San Lucas, Huatulco (Santa María Huatulco), Cruising Panama Canal and Colón and 2 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- MSC Poesia
- Cruise line
- MSC Cruises
- Duration
- 19 nights
- Region
- World Cruise
- Departs
- Seattle, Washington
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact MSC Poesia sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1

Seattle, Washington
Depart 18:00
A port city in Washington State on Puget Sound, framed by Mount Rainier and the Olympic Mountains. Seattle is a major gateway to Alaska cruises, known for Pike Place Market, the Space Needle, and the original Starbucks near the waterfront.
- Pike Place Market
- Space Needle
- Puget Sound
- Day2At sea
- Day3At sea
- Day4At sea
- Day5

Los Angeles, California
Arrive 07:00 · Depart 21:00
The sprawling Pacific gateway of southern California, with most cruises sailing from the neighbouring Port of Los Angeles at San Pedro. The morning leaves time for Hollywood, the beaches at Santa Monica or the galleries downtown before departure.
- Hollywood
- Santa Monica Pier
- Getty Center
- Day6

San Diego, California
Arrive 08:00 · Depart 18:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day7At sea
- Day8At sea
- Day9

Cabo San Lucas
Arrive 07:00 · Depart 16:00
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day10At sea
- Day11At sea
- Day12

Huatulco (Santa María Huatulco)
Arrive 07:00 · Depart 16:00
- Day13At sea
- Day14At sea
- Day15
Cruising Panama Canal
Arrive 09:00 · Depart 09:15
Cruising Panama Canal
Arrive 21:00 · Depart 21:15
- Day16

Colón
Arrive 07:00 · Depart 19:00
A Caribbean port at the Atlantic entrance to the Panama Canal, the usual landing for ships transiting or calling at the isthmus. The historic Gatún Locks and rainforest waterways lie close by, along with the duty-free trade zone and the old fortifications of Portobelo.
- Gatún Locks
- Panama Canal
- Portobelo forts
- Day17

Cartagena
Arrive 11:00 · Depart 18:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day18At sea
- Day19At sea
- Day20

Miami, Florida
Arrive 07:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 27 Sep 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
19-Night World Cruise Cruise from Seattle, Washington FAQ
Which ports does this cruise visit?
This 19-night World Cruise cruise calls at Seattle, Washington, Los Angeles, California, San Diego, California, Cabo San Lucas, Huatulco (Santa María Huatulco), Cruising Panama Canal, Colón, Cartagena and Miami, Florida.
How many days are spent at sea?
12 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Seattle, Washington and ends in Miami, Florida.
How long is this cruise?
19 nights aboard MSC Poesia.
When does this itinerary sail?
Upcoming departures include 27 Sep 2027. A NestCruise advisor can confirm current availability.