Oosterdam — 21-Night Europe Cruise from Piraeus

Cruise itinerary

21-Night Europe Cruise from Piraeus

21 nights · Europe · 9 ports of call

21-night Europe cruise aboard Oosterdam, departing Piraeus and calling at Náfplion, Istanbul, Kusadasi, Santorini, Rhodes and Khania and 2 more.

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At a glance

Ship: Oosterdam
Cruise line: Holland America Line
Duration: 21 nights
Region: Europe · Southern Europe · Mediterranean
Departs: Piraeus
Returns: Piraeus

How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oosterdam sailing, typically within 24 hours.

Where this voyage takes you

Voyage route — calls shown in order; map is schematic.

Day-by-day itinerary

Day
1
- Piraeus
  Depart 17:00
  The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
  - Gateway to Athens
  - Acropolis
  - Aegean ferries
Day
2
- Náfplion
  Arrive 08:00 · Depart 17:00
  A harbour town in the Peloponnese, the first capital of modern Greece, set beneath the Palamidi fortress. Its neoclassical old town runs down to the waterfront, with the small Bourtzi castle standing on an islet in the bay.
  - Palamidi fortress
  - Bourtzi castle
  - Old town squares
Day
3
At sea
Day
4
- Istanbul
  Arrive 08:00
  The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
  - Hagia Sophia
  - Blue Mosque
  - Grand Bazaar
Day
5
- Istanbul
  Depart 17:00
  The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
  - Hagia Sophia
  - Blue Mosque
  - Grand Bazaar
Day
6
At sea
Day
7
- Kusadasi
  Arrive 08:00 · Depart 17:00
  A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
  - Ephesus ruins
  - Library of Celsus
  - Pigeon Island
Day
8
- Santorini
  Arrive 08:00 · Depart 17:00
  The crescent rim of a flooded volcanic caldera in the Greek Cyclades, its whitewashed villages strung along cliffs high above the sea. Fira and Oia draw crowds for sunset views, while the caldera's dark beaches and the ancient site of Akrotiri lie below.
  - Oia sunset
  - Fira town
  - Caldera cliffs
Day
9
- Rhodes
  Arrive 08:00 · Depart 23:00
  The largest of Greece's Dodecanese islands, off the Turkish coast, with one of Europe's best-preserved medieval walled towns. The Old Town keeps the cobbled Street of the Knights and the Palace of the Grand Master, while Lindos and its acropolis lie down the coast.
  - Medieval Old Town
  - Palace of the Grand Master
  - Lindos Acropolis
Day
10
At sea
Day
11
- Khania
  Arrive 07:00 · Depart 17:00
  A harbour town on the northwest coast of Crete, in Greece, wrapped around a Venetian port. A waterfront lighthouse marks the old harbour mouth, and the pink-sand lagoon of Balos and the beach at Elafonisi lie along the coast to the west.
  - Venetian harbour
  - Balos lagoon
  - Elafonisi beach
Day
12
- Piraeus
  Arrive 07:00 · Depart 17:00
  The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
  - Gateway to Athens
  - Acropolis
  - Aegean ferries
Day
13
- Mykonos
  Arrive 07:00 · Depart 20:00
  A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
  - Windmills
  - Little Venice
  - Chora town
Day
14
At sea
Day
15
- Istanbul
  Arrive 07:00
  The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
  - Hagia Sophia
  - Blue Mosque
  - Grand Bazaar
Day
16
- Istanbul
  Depart 23:00
  The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
  - Hagia Sophia
  - Blue Mosque
  - Grand Bazaar
Day
17
At sea
Day
18
- Kusadasi
  Arrive 07:00 · Depart 19:00
  A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
  - Ephesus ruins
  - Library of Celsus
  - Pigeon Island
Day
19
- Kos
  Arrive 08:00 · Depart 18:00
Day
20
- Rhodes
  Arrive 08:00 · Depart 21:00
  The largest of Greece's Dodecanese islands, off the Turkish coast, with one of Europe's best-preserved medieval walled towns. The Old Town keeps the cobbled Street of the Knights and the Palace of the Grand Master, while Lindos and its acropolis lie down the coast.
  - Medieval Old Town
  - Palace of the Grand Master
  - Lindos Acropolis
Day
21
At sea
Day
22
- Piraeus
  Arrive 07:00
  The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
  - Gateway to Athens
  - Acropolis
  - Aegean ferries

Upcoming departures

3 Oct 2026

Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.

21-Night Europe Cruise from Piraeus FAQ

Which ports does this cruise visit?

This 21-night Europe cruise calls at Piraeus, Náfplion, Istanbul, Kusadasi, Santorini, Rhodes, Khania, Mykonos and Kos.

How many days are spent at sea?

6 days are spent at sea; the rest are in port.

Where does this cruise depart from?

It is a round-trip sailing from Piraeus.

How long is this cruise?

21 nights aboard Oosterdam.

When does this itinerary sail?

Upcoming departures include 3 Oct 2026. A NestCruise advisor can confirm current availability.

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About: Oosterdam — 21-Night Europe Cruise from Piraeus

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