Cruise itinerary
21-Night Europe Cruise from Piraeus
21 nights · Europe · 17 ports of call
21-night Europe cruise aboard Oosterdam, departing Piraeus and calling at Mykonos, Istanbul, Kusadasi, Kos, Rhodes and Katakolon and 10 more.
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- No booking fees
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At a glance
- Ship
- Oosterdam
- Cruise line
- Holland America Line
- Duration
- 21 nights
- Region
- Europe · Southern Europe · Mediterranean · Adriatic
- Departs
- Piraeus
- Returns
- Barcelona
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oosterdam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Piraeus
Depart 17:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day2
Mykonos
Arrive 07:00 · Depart 20:00
A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
- Windmills
- Little Venice
- Chora town
- Day3At sea
- Day4
Istanbul
Arrive 07:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day5
Istanbul
Depart 23:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day6At sea
- Day7
Kusadasi
Arrive 07:00 · Depart 19:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day8
Kos
Arrive 08:00 · Depart 18:00
- Day9
Rhodes
Arrive 08:00 · Depart 21:00
The largest of Greece's Dodecanese islands, off the Turkish coast, with one of Europe's best-preserved medieval walled towns. The Old Town keeps the cobbled Street of the Knights and the Palace of the Grand Master, while Lindos and its acropolis lie down the coast.
- Medieval Old Town
- Palace of the Grand Master
- Lindos Acropolis
- Day10At sea
- Day11
Piraeus
Arrive 07:00 · Depart 17:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day12
Katakolon
Arrive 08:00 · Depart 16:00
A small port on Greece's western Peloponnese coast, best known as the gateway to ancient Olympia. The sanctuary where the original Olympic Games were held lies a short drive inland, among ruined temples and the old stadium.
- Ancient Olympia
- Olympic stadium
- Temple of Zeus
- Day13
Sarandë
Arrive 10:00 · Depart 18:00
A coastal town in southern Albania on the Ionian Sea, facing the Greek island of Corfu across a narrow strait. Its curved bay and beaches anchor the town, and the ancient ruins of Butrint lie a short way down the coast.
- Butrint ruins
- Ionian beaches
- Lëkurësi Castle
- Day14At sea
- Day15
Valletta
Arrive 08:00 · Depart 20:00
Malta's fortified harbour capital, built by the Knights of St. John on a peninsula between two deep ports. Honey-coloured limestone defines St. John's Co-Cathedral, the Grand Master's Palace and the bastions overlooking the Grand Harbour.
- Grand Harbour
- St. John's Co-Cathedral
- Upper Barrakka Gardens
- Day16
Stromboli
Messina
Arrive 08:00 · Depart 17:00
A Sicilian port on the strait that separates the island from mainland Italy, framed by the Peloritani mountains. Its harbour clock tower performs an elaborate noon display, and the town is a common gateway to Taormina and the slopes of Mount Etna.
- Etna day trips
- Taormina gateway
- Astronomical clock
- Day17
Naples
Arrive 07:00 · Depart 18:00
A southern Italian port on its namesake bay, in the shadow of Mount Vesuvius. Ships dock near the historic centre, the gateway to Pompeii, the cliffs of the Amalfi Coast and the island of Capri, in a city that claims to have invented pizza.
- Mount Vesuvius
- Pompeii
- Gateway to Capri
- Day18
Civitavecchia
Arrive 07:00 · Depart 22:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day19
Bonifacio, Corsica
Ajaccio, Corsica
Arrive 10:00 · Depart 18:00
The capital of Corsica and Napoleon's birthplace, set on a sheltered gulf on the island's west coast. Ajaccio is known for its Bonaparte family house, the citadel and old town, and the rugged Sanguinaires islands off the harbour mouth.
- Maison Bonaparte
- Sanguinaires islands
- Ajaccio citadel
- Day20
Villefranche-sur-Mer
Arrive 08:00 · Depart 17:00
A deep-water bay on the French Riviera between Nice and Monaco, framed by steep pastel hillsides. The sheltered harbour is a classic tender anchorage, with a baroque old town behind the waterfront and easy connections along the coast to Nice and Monte Carlo.
- Old town
- Riviera coast
- Nice & Monaco access
- Day21At sea
- Day22
Barcelona
Arrive 07:00
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
Upcoming departures
- 14 Oct 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
21-Night Europe Cruise from Piraeus FAQ
Which ports does this cruise visit?
This 21-night Europe cruise calls at Piraeus, Mykonos, Istanbul, Kusadasi, Kos, Rhodes, Katakolon, Sarandë, Valletta, Stromboli, Messina, Naples, Civitavecchia, Bonifacio, Corsica, Ajaccio, Corsica, Villefranche-sur-Mer and Barcelona.
How many days are spent at sea?
5 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Piraeus and ends in Barcelona.
How long is this cruise?
21 nights aboard Oosterdam.
When does this itinerary sail?
Upcoming departures include 14 Oct 2026. A NestCruise advisor can confirm current availability.