Royal Caribbean International · Serenade of the Seas · Itinerary
16-Night Americas Cruise from San Diego, California
16-night Americas cruise aboard Serenade of the Seas, departing San Diego, California and calling at Puerto Vallarta, Puerto Quetzal, Puntarenas, Panama Canal Transit, Cartagena and Georgetown, Grand Cayman and 1 more.
Voyage route — calls shown in order; map is schematic.
Family Friendly
day by day
Day-by-day itinerary
Day 1
San Diego, California
Depart 17:00
Day 4
Puerto Vallarta
Arrive 08:00 · Depart 17:00
Day 7
Puerto Quetzal
Arrive 08:00 · Depart 17:00
Day 9
Puntarenas
Arrive 08:00 · Depart 17:00
Day 11
P
Panama Canal Transit
Arrive 06:00 · Depart 18:00
Day 12
Cartagena
Arrive 11:30 · Depart 19:00
Day 14
Georgetown, Grand Cayman
Arrive 07:00 · Depart 16:00
Day 16
Tampa, Florida
Arrive 05:00
when to sail
Upcoming departures
7 Oct 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
good to know
16-Night Americas Cruise from San Diego, California FAQ
Which ports does this cruise visit?
This 16-night Americas cruise calls at San Diego, California, Puerto Vallarta, Puerto Quetzal, Puntarenas, Panama Canal Transit, Cartagena, Georgetown, Grand Cayman and Tampa, Florida.
How many days are spent at sea?
This is a port-intensive itinerary with no full days at sea.
Where does this cruise depart from?
It departs from San Diego, California and ends in Tampa, Florida.
How long is this cruise?
16 nights aboard Serenade of the Seas.
When does this itinerary sail?
Upcoming departures include 7 Oct 2027. A NestCruise advisor can confirm current availability.
settle in, sail beyond.
Narrow your 16-night sailing
Tell us your dates and group — a NestCruise advisor narrows this voyage to the right cabin and confirms your live fare. No booking fees.
