Regent Seven Seas Cruises · Seven Seas Prestige · Itinerary
27-Night Americas Cruise from Panama City
27-night Americas cruise aboard Seven Seas Prestige, departing Panama City and calling at Panama Canal Transit, Cartagena, Cruising the Caribbean Sea, Oranjestad, Willemstad and Saint George's and 10 more.
Voyage route — calls shown in order; map is schematic.
day by day
Day-by-day itinerary
Day 1
Panama City
Arrive 07:00 · Depart 16:00
Day 2
P
Panama Canal Transit
Day 3
Cartagena
Arrive 12:00 · Depart 20:00
Day 4
C
Cruising the Caribbean Sea
Day 5
Oranjestad
Arrive 07:00 · Depart 17:00
Day 6
Willemstad
Arrive 07:00 · Depart 17:00
Day 7
C
Cruising the Caribbean Sea
Day 8
S
Saint George's
Arrive 07:00 · Depart 17:00
Day 9
Roseau
Arrive 07:00 · Depart 16:00
Day 10
Charlotte Amalie
Arrive 09:00 · Depart 17:00
St. Thomas's harbour town in the U.S. Virgin Islands — a deep, sheltered bay ringed by red-roofed hills. Known for duty-free shopping along Main Street and the easy hop to Magens Bay or a ferry across to quieter St. John.
Magens Bay
Main Street shopping
ferry to St. John
Day 11
S
Sailing the Atlantic Ocean
Day 12
C
Cruising the Bahamian Waters
Day 13
Miami, Florida
Arrive 07:00 · Depart 16:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
South Beach
Little Havana
Wynwood murals
Day 14
S
Sailing the Atlantic Ocean
Day 15
S
Sailing the Atlantic Ocean
Day 16
Kings Wharf
Arrive 09:00
Day 17
Kings Wharf
Depart 15:00
Day 18
S
Sailing the Atlantic Ocean
Day 19
S
Sailing the Atlantic Ocean
Day 20
S
Sailing the Atlantic Ocean
Day 21
S
Sailing the Atlantic Ocean
Day 22
Ponta Delgada, Azores
Arrive 10:00 · Depart 18:00
Day 23
S
Sailing the Atlantic Ocean
Day 24
Funchal, Madeira
Arrive 08:00 · Depart 17:00
Day 25
S
Sailing the Atlantic Ocean
Day 26
Cádiz
Arrive 07:00 · Depart 16:00
Day 27
Lisbon
Arrive 07:00 · Depart 16:00
when to sail
Upcoming departures
14 Mar 2028
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
good to know
27-Night Americas Cruise from Panama City FAQ
Which ports does this cruise visit?
This 27-night Americas cruise calls at Panama City, Panama Canal Transit, Cartagena, Cruising the Caribbean Sea, Oranjestad, Willemstad, Saint George's, Roseau, Charlotte Amalie, Sailing the Atlantic Ocean, Cruising the Bahamian Waters, Miami, Florida, Kings Wharf, Ponta Delgada, Azores, Funchal, Madeira, Cádiz and Lisbon.
How many days are spent at sea?
3 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Panama City and ends in Lisbon.
How long is this cruise?
27 nights aboard Seven Seas Prestige.
When does this itinerary sail?
Upcoming departures include 14 Mar 2028. A NestCruise advisor can confirm current availability.
settle in, sail beyond.
Narrow your 27-night sailing
Tell us your dates and group — a NestCruise advisor narrows this voyage to the right cabin and confirms your live fare. No booking fees.
