Regent Seven Seas Cruises · Seven Seas Prestige · Itinerary
12-Night Americas Cruise from Panama City
12-night Americas cruise aboard Seven Seas Prestige, departing Panama City and calling at Panama Canal Transit, Puerto Limón, Cruising the Caribbean Sea, Roatán Island, Harvest Caye and Santo Tomás de Castilla and 5 more.
Voyage route — calls shown in order; map is schematic.
day by day
Day-by-day itinerary
Day 1
Panama City
Arrive 07:00 · Depart 17:00
Day 2
P
Panama Canal Transit
Arrive 06:00 · Depart 18:00
Day 3
Puerto Limón
Arrive 08:00 · Depart 18:00
Day 4
C
Cruising the Caribbean Sea
Day 5
Roatán Island
Arrive 11:00 · Depart 18:00
Day 6
Harvest Caye
Arrive 08:00 · Depart 17:00
Day 7
Santo Tomás de Castilla
Arrive 07:00 · Depart 13:00
Day 8
C
Cozumel
Arrive 08:00 · Depart 15:00
Day 9
G
Georgetown, Grand Cayman
Arrive 11:00 · Depart 16:00
Day 10
Montego Bay
Arrive 07:00 · Depart 13:00
Day 11
C
Cruising the Florida Straits
Day 12
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
South Beach
Little Havana
Wynwood murals
when to sail
Upcoming departures
22 Feb 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
good to know
12-Night Americas Cruise from Panama City FAQ
Which ports does this cruise visit?
This 12-night Americas cruise calls at Panama City, Panama Canal Transit, Puerto Limón, Cruising the Caribbean Sea, Roatán Island, Harvest Caye, Santo Tomás de Castilla, Cozumel, Georgetown, Grand Cayman, Montego Bay, Cruising the Florida Straits and Miami, Florida.
How many days are spent at sea?
2 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Panama City and ends in Miami, Florida.
How long is this cruise?
12 nights aboard Seven Seas Prestige.
When does this itinerary sail?
Upcoming departures include 22 Feb 2027. A NestCruise advisor can confirm current availability.
settle in, sail beyond.
Narrow your 12-night sailing
Tell us your dates and group — a NestCruise advisor narrows this voyage to the right cabin and confirms your live fare. No booking fees.
