Regent Seven Seas Cruises · Seven Seas Grandeur · Itinerary

15-Night Americas Cruise from Miami, Florida

15-night Americas cruise aboard Seven Seas Grandeur, departing Miami, Florida and calling at Cruising the Florida Straits, Costa Maya, Harvest Caye, Roatán Island, Cruising the Caribbean Sea and Georgetown, Grand Cayman and 6 more.

15 nightsAmericas13 ports of call

Narrow your sailing dates →

Ship

Seven Seas Grandeur

Cruise line

Regent Seven Seas Cruises

Duration

15 nights

Region

Americas · South America · Panama Canal

Departs

Miami, Florida

Returns

Panama City

the voyage

Where this voyage takes you

Voyage route — calls shown in order; map is schematic.

day by day

Day-by-day itinerary

Day 1
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Day 2
Cruising the Florida Straits
Day 3
Costa Maya
Arrive 07:00 · Depart 17:00
Day 4
Harvest Caye
Arrive 07:00 · Depart 17:00
Day 5
Roatán Island
Arrive 07:00 · Depart 17:00
Day 6
Cruising the Caribbean Sea
Day 7
Georgetown, Grand Cayman
Arrive 07:00 · Depart 16:00
Day 8
Ocho Rios
Arrive 09:00 · Depart 17:00
Day 9
Cruising the Caribbean Sea
Day 10
Puerto Limón
Arrive 10:30 · Depart 19:30
Day 11
Cruising the Caribbean Sea
Day 12
Cartagena
Arrive 07:00 · Depart 14:30
Day 13
Colón
Arrive 08:00 · Depart 18:00
Day 14
Panama Canal Transit
Arrive 07:00 · Depart 19:00
Panama City
Arrive 20:00
Day 15
Panama City
Depart 17:00

when to sail

Upcoming departures

23 Feb 2027

Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.

good to know

15-Night Americas Cruise from Miami, Florida FAQ

Which ports does this cruise visit?

This 15-night Americas cruise calls at Miami, Florida, Cruising the Florida Straits, Costa Maya, Harvest Caye, Roatán Island, Cruising the Caribbean Sea, Georgetown, Grand Cayman, Ocho Rios, Puerto Limón, Cartagena, Colón, Panama Canal Transit and Panama City.

How many days are spent at sea?

4 days are spent at sea; the rest are in port.

Where does this cruise depart from?

It departs from Miami, Florida and ends in Panama City.

How long is this cruise?

15 nights aboard Seven Seas Grandeur.

When does this itinerary sail?

Upcoming departures include 23 Feb 2027. A NestCruise advisor can confirm current availability.

settle in, sail beyond.

Narrow your 15-night sailing

Tell us your dates and group — a NestCruise advisor narrows this voyage to the right cabin and confirms your live fare. No booking fees.