48-night Mediterranean cruise aboard Oceania Insignia, departing Barcelona and calling at Palma de Mallorca, Alicante, Cartagena, Málaga, Seville and Portimão and 21 more.
Voyage route — calls shown in order; map is schematic.
day by day
Day-by-day itinerary
Day 1
Barcelona
Arrive 07:00 · Depart 17:00
Day 2
Palma de Mallorca
Arrive 08:00 · Depart 18:00
Day 3
Alicante
Arrive 08:00 · Depart 18:00
Day 4
Cartagena
Arrive 07:00 · Depart 17:00
Day 5
Málaga
Arrive 08:00 · Depart 19:00
Day 6
Seville
Arrive 07:00 · Depart 19:00
Day 7
Portimão
Arrive 07:00 · Depart 17:00
Day 8
Lisbon
Arrive 07:00 · Depart 17:00
Day 9
A
At Sea
Day 10
Arrecife, Lanzarote
Arrive 10:00 · Depart 18:00
Day 11
Las Palmas de Gran Canaria
Arrive 07:00 · Depart 17:00
Day 12
Santa Cruz de La Palma
Arrive 07:00 · Depart 17:00
Day 13
A
At Sea
Day 14
A
At Sea
Day 15
A
At Sea
Day 16
A
At Sea
Day 17
A
At Sea
Day 18
A
At Sea
Day 19
San Juan (Puerto Rico)
Arrive 11:00
Day 20
San Juan (Puerto Rico)
Depart 11:00
Day 21
A
At Sea
Day 22
Nassau
Arrive 11:00 · Depart 17:00
Day 23
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
South Beach
Little Havana
Wynwood murals
Day 24
A
At Sea
Day 25
A
At Sea
Day 26
Tortola
Arrive 10:00 · Depart 18:00
Day 27
Saint John's
Arrive 07:00 · Depart 17:00
Day 28
Castries
Arrive 08:00 · Depart 17:00
Day 29
Scarborough
Arrive 07:00 · Depart 16:00
Day 30
A
At Sea
Day 31
A
At Sea
Day 32
C
Cruising Amazon River
Arrive 10:00 · Depart 11:00
Day 33
S
Santarém
Arrive 09:00 · Depart 18:00
Day 34
B
Boca de Valeria
Arrive 07:00 · Depart 15:00
Day 35
Manaus
Arrive 10:00
Day 36
Manaus
Depart 16:00
Day 37
P
Parintins
Arrive 11:00 · Depart 19:00
Day 38
A
Alter do Chão
Arrive 07:30 · Depart 15:00
Day 39
C
Cruising Amazon River
Arrive 13:00 · Depart 14:00
Day 40
A
At Sea
Day 41
A
At Sea
Day 42
Bridgetown
Arrive 11:00 · Depart 18:00
Day 43
Roseau
Arrive 08:00 · Depart 18:00
Day 44
Philipsburg
Arrive 08:00 · Depart 17:00
The Dutch-side capital of St. Maarten, set behind the long curve of Great Bay. Front Street is wall-to-wall duty-free; a short water taxi or drive reaches the French side's Marigot market and the famous low-flying jets over Maho Beach.
Great Bay Beach
Front Street duty-free
Maho Beach plane-spotting
Day 45
San Juan (Puerto Rico)
Arrive 07:00 · Depart 13:00
Day 46
A
At Sea
Day 47
Nassau
Arrive 11:30 · Depart 17:00
Day 48
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
South Beach
Little Havana
Wynwood murals
when to sail
Upcoming departures
2 Nov 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
good to know
48-Night Mediterranean Cruise from Barcelona FAQ
Which ports does this cruise visit?
This 48-night Mediterranean cruise calls at Barcelona, Palma de Mallorca, Alicante, Cartagena, Málaga, Seville, Portimão, Lisbon, At Sea, Arrecife, Lanzarote, Las Palmas de Gran Canaria, Santa Cruz de La Palma, San Juan (Puerto Rico), Nassau, Miami, Florida, Tortola, Saint John's, Castries, Scarborough, Cruising Amazon River, Santarém, Boca de Valeria, Manaus, Parintins, Alter do Chão, Bridgetown, Roseau and Philipsburg.
How many days are spent at sea?
17 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Barcelona and ends in Miami, Florida.
How long is this cruise?
48 nights aboard Oceania Insignia.
When does this itinerary sail?
Upcoming departures include 2 Nov 2026. A NestCruise advisor can confirm current availability.
settle in, sail beyond.
Narrow your 48-night sailing
Tell us your dates and group — a NestCruise advisor narrows this voyage to the right cabin and confirms your live fare. No booking fees.
