16-Night World Cruise Cruise from Los Angeles, California
16-night World Cruise cruise aboard MSC Poesia, departing Los Angeles, California and calling at San Diego, California, Cabo San Lucas, Puntarenas, Cruising Panama Canal, Colón and Cartagena and 1 more.
Voyage route — calls shown in order; map is schematic.
day by day
Day-by-day itinerary
Day 1
Los Angeles, California
Depart 21:00
Day 2
S
San Diego, California
Arrive 08:00 · Depart 18:00
Day 5
C
Cabo San Lucas
Arrive 07:00 · Depart 16:00
Day 9
Puntarenas
Arrive 10:00 · Depart 20:00
Day 11
C
Cruising Panama Canal
Arrive 09:00 · Depart 09:15
C
Cruising Panama Canal
Arrive 21:00 · Depart 21:15
Day 12
Colón
Arrive 07:00 · Depart 19:00
Day 13
Cartagena
Arrive 11:00 · Depart 18:00
Day 16
Miami, Florida
Arrive 07:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
South Beach
Little Havana
Wynwood murals
when to sail
Upcoming departures
2 Oct 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
good to know
16-Night World Cruise Cruise from Los Angeles, California FAQ
Which ports does this cruise visit?
This 16-night World Cruise cruise calls at Los Angeles, California, San Diego, California, Cabo San Lucas, Puntarenas, Cruising Panama Canal, Colón, Cartagena and Miami, Florida.
How many days are spent at sea?
1 day is spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Los Angeles, California and ends in Miami, Florida.
How long is this cruise?
16 nights aboard MSC Poesia.
When does this itinerary sail?
Upcoming departures include 2 Oct 2026. A NestCruise advisor can confirm current availability.
settle in, sail beyond.
Narrow your 16-night sailing
Tell us your dates and group — a NestCruise advisor narrows this voyage to the right cabin and confirms your live fare. No booking fees.
