19-Night Caribbean Cruise from San Diego, California
19-night Caribbean cruise aboard Crystal Serenity, departing San Diego, California and calling at At Sea, Topolobampo, La Paz, Isla Natividad, Manzanillo, Mexico and Puerto Vallarta and 2 more.
Voyage route — calls shown in order; map is schematic.
day by day
Day-by-day itinerary
Day 1
San Diego, California
Day 2
A
At Sea
Day 3
A
At Sea
Day 4
T
Topolobampo
Day 5
A
At Sea
Day 7
La Paz
Day 8
A
At Sea
Day 9
I
Isla Natividad
Day 10
San Diego, California
Day 11
A
At Sea
Day 12
A
At Sea
Day 13
Manzanillo, Mexico
Day 14
Puerto Vallarta
Day 15
Mazatlán
Day 16
Cabo San Lucas
Day 17
Cabo San Lucas
Day 18
A
At Sea
Day 19
San Diego, California
when to sail
Upcoming departures
21 Dec 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
good to know
19-Night Caribbean Cruise from San Diego, California FAQ
Which ports does this cruise visit?
This 19-night Caribbean cruise calls at San Diego, California, At Sea, Topolobampo, La Paz, Isla Natividad, Manzanillo, Mexico, Puerto Vallarta, Mazatlán and Cabo San Lucas.
How many days are spent at sea?
7 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from San Diego, California.
How long is this cruise?
19 nights aboard Crystal Serenity.
When does this itinerary sail?
Upcoming departures include 21 Dec 2026. A NestCruise advisor can confirm current availability.
settle in, sail beyond.
Narrow your 19-night sailing
Tell us your dates and group — a NestCruise advisor narrows this voyage to the right cabin and confirms your live fare. No booking fees.
