Regent Seven Seas Cruises · Seven Seas Grandeur · Itinerary
23-Night Americas Cruise from Panama City
23-night Americas cruise aboard Seven Seas Grandeur, departing Panama City and calling at Panama Canal Transit, Cruising the Caribbean Sea, Oranjestad, Port-of-Spain, Sailing the Atlantic Ocean and Cruising Amazon River and 5 more.
Voyage route — calls shown in order; map is schematic.
day by day
Day-by-day itinerary
Day 1
Panama City
Depart 17:00
Day 2
P
Panama Canal Transit
Arrive 06:00 · Depart 18:00
Day 3
C
Cruising the Caribbean Sea
Day 4
Oranjestad
Arrive 10:00 · Depart 19:00
Day 5
C
Cruising the Caribbean Sea
Day 6
P
Port-of-Spain
Arrive 07:00 · Depart 13:00
Day 7
S
Sailing the Atlantic Ocean
Day 8
S
Sailing the Atlantic Ocean
Day 9
C
Cruising Amazon River
Day 10
C
Cruising Amazon River
Day 11
Manaus
Arrive 07:00
Day 12
Manaus
Depart 16:00
Day 13
B
Boca de Valeria
Arrive 10:00 · Depart 17:00
Day 14
A
Alter do Chão
Arrive 07:30 · Depart 15:00
Day 15
C
Cruising Amazon River
Day 16
S
Sailing the Atlantic Ocean
Day 17
S
Sailing the Atlantic Ocean
Day 18
S
Saint George's
Arrive 11:00 · Depart 18:00
Day 19
C
Cruising the Caribbean Sea
Day 20
Willemstad
Arrive 07:00 · Depart 14:00
Day 21
C
Cruising the Caribbean Sea
Day 22
P
Panama Canal Transit
Arrive 06:00 · Depart 18:00
Day 23
Panama City
Arrive 07:00
when to sail
Upcoming departures
9 Mar 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
good to know
23-Night Americas Cruise from Panama City FAQ
Which ports does this cruise visit?
This 23-night Americas cruise calls at Panama City, Panama Canal Transit, Cruising the Caribbean Sea, Oranjestad, Port-of-Spain, Sailing the Atlantic Ocean, Cruising Amazon River, Manaus, Boca de Valeria, Alter do Chão, Saint George's and Willemstad.
How many days are spent at sea?
7 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from Panama City.
How long is this cruise?
23 nights aboard Seven Seas Grandeur.
When does this itinerary sail?
Upcoming departures include 9 Mar 2027. A NestCruise advisor can confirm current availability.
settle in, sail beyond.
Narrow your 23-night sailing
Tell us your dates and group — a NestCruise advisor narrows this voyage to the right cabin and confirms your live fare. No booking fees.
